
Head coach Gerardo Seoane made a total of six changes from the weekend’s 2-2 draw with Köln. Edmond Tapsoba, Mitchel Bakker, Exequiel Palacios, Amine Adli, Nadiem Amiri and Paulinho all started in place of Odilon Kossounou, Piero Hincapie, Kerem Demirbay, Florian Wirtz (all on the bench), Karim Bellarabi (thigh strain) and Patrik Schick (ankle).
Striker Lucas Alario was also unavailable due to a muscular problem, but there was good news as Iker Bravo took his place in the senior squad for the first time. The 16-year-old centre-forward moved to Leverkusen from Barcelona in the summer and was on the bench.
It was a bad start for Bayer 04 as they fell behind inside only four minutes. A cross from the left was met by the unmarked Philipp Hofmann in the middle, but Lukas Hradecky still made an excellent reaction stop. However, he couldn’t hold onto the ball and Lucas Cueto was the quickest to react and put Karlsruhe ahead. The Werkself didn’t take it lying down and twice came within inches of a reply, first through Moussa Diaby and then Adli.

There was no lack of commitment or speed from Paulinho & Co as the visitors dropped further and further back into their own half, making it tough for Bayer 04 to pose a threat to goalkeeper Marius Gersbeck. A weak volley from Amiri and an effort from Robert Andrich that went over the bar was the best it got. Seoane’s troops had over 65% possession by the break, but couldn’t find a way through the Karlsruhe defence as it remained 1-0 after 45 minutes.
The second half got off to a fast pace. Captain Hradecky had to save a free-kick from Marvin Wanitzek before Karlsruhe skipper Jerome Gondorf got in a crucial block to deny Amiri at the other end. The Werkself finally had their breakthrough after 54 minutes when Jeremie Frimpong played a great one-two with Adli in the box and fired the ball into the top left corner for the equaliser.
Bayer 04 then failed to convert their supremacy into further chances. A lack of accuracy in the final third meant shooting opportunities were at a premium. But the visitors showed they could be clinical and restored the lead with their next chance. Hradecky played a pass straight to the feet of striker Kyoung-Rok Choi, who finished to make it 2-1.
Seoane reacted by sending on Demirbay and Wirtz. The Werkself were even more dominant with their two playmakers on the pitch and launched attack after attack, but ultimately to no avail. Adli and debutant substitute Bravo both fired over from central positions. Leverkusen pushed until the end for an equaliser, but Karlsruhe threw everything they could into blocks and challenges to get their 2-1 win over the line.

Next up for Bayer 04 is another home game against Wolfsburg on Saturday, 30 October in the Bundesliga. Kick-off at the BayArena is at 15:30 CEST.
Stats:
Bayer 04: Hradecky – Frimpong, Tah, Tapsoba, Bakker (Sinkgraven 77') – Palacios (Demirbay 64'), Andrich – Diaby, Amiri (Wirtz 64'), Adli – Paulinho (Bravo 77')
Karlsruhe: Gersbeck – Thiede, Gordon, Kobald, Heise (Jakob 86') – Breithaupt (Batmaz 81') – Choi, Wanitzek, Gondorf, Cueto (Lorenz 66') – Hofmann (Schleusener 81')
Goals: 0-1 Cueto (4'), 1-1 Frimpong (54'), 1-2 Choi (64')
Yellow cards: Frimpong, Tah – Gordon
Referee: Tobias Welz (Wiesbaden)
Attendance: 13,060

Bayer 04 Leverkusen have loaned U19 midfielder Jeremiah Mensah to Dutch second-tier side Roda JC Kerkrade for one year. The 18-year-old Germany youth international has a long-term contract at the club to 2031.
Show more
Bayer 04 kick off the final phase of their 2026/27 pre-season preparations with a friendly against Premier League club Nottingham Forest. Head coach Carles Martínez’s team will take to the pitch at the City Ground today, Wednesday 12 August (kick-off: 8.45 pm/7.45 pm local time). Werkself-TV will broadcast the match live and in full exclusively for Bayer 04 members via livestream from 8.35 pm...

Bayer 04 Leverkusen have signed Argentina international Facundo Medina. The defender, who can play both at left-back and in a more central position in the back line, has signed a contract with Bayer 04 to 30 June 2031. The 1.84-metre-tall World Cup runner-up, who will wear the number 2 shirt, joins the club from French top-flight side Olympique de Marseille.
Show more
Villa Fiorito, River Plate, Ligue 1, the World Cup final and now Bayer 04: Facundo Medina’s life story so far has been shaped by special places, clubs, matches and names. One of them is Diego Maradona, who, like Medina, hailed from the south of Buenos Aires. Another is Exequiel Palacios, his former team-mate at River Plate, who was raving about Bayer 04 to him as recently as the World Cup in North America. Medina has now taken the plunge into the Bundesliga and, as an Argentine World Cup runner-up, has joined Bayer 04 from Olympique de Marseille this week. It is set to be the next successful chapter in his career. Leverkusen’s new number 2 brings with him a South American mentality and passion, a wealth of experience from many years in Ligue 1, and a fascinating story to the Rhineland – and to a club where the 1.84-metre-tall left-footed player will be reunited with Palacios and several other familiar faces.
Show more
Shortly after signing his contract with Bayer 04, new signing Facundo Medina spoke to Werkself.tv about his first impressions of the club, his expectations and his conversations with his Argentine compatriot Exequiel Palacios. The defender also reveals what the fans can look forward to. Welcome to Leverkusen, Facu!
Show more