
Head coach Gerardo Seoane made a total of six changes from the weekend’s 2-2 draw with Köln. Edmond Tapsoba, Mitchel Bakker, Exequiel Palacios, Amine Adli, Nadiem Amiri and Paulinho all started in place of Odilon Kossounou, Piero Hincapie, Kerem Demirbay, Florian Wirtz (all on the bench), Karim Bellarabi (thigh strain) and Patrik Schick (ankle).
Striker Lucas Alario was also unavailable due to a muscular problem, but there was good news as Iker Bravo took his place in the senior squad for the first time. The 16-year-old centre-forward moved to Leverkusen from Barcelona in the summer and was on the bench.
It was a bad start for Bayer 04 as they fell behind inside only four minutes. A cross from the left was met by the unmarked Philipp Hofmann in the middle, but Lukas Hradecky still made an excellent reaction stop. However, he couldn’t hold onto the ball and Lucas Cueto was the quickest to react and put Karlsruhe ahead. The Werkself didn’t take it lying down and twice came within inches of a reply, first through Moussa Diaby and then Adli.

There was no lack of commitment or speed from Paulinho & Co as the visitors dropped further and further back into their own half, making it tough for Bayer 04 to pose a threat to goalkeeper Marius Gersbeck. A weak volley from Amiri and an effort from Robert Andrich that went over the bar was the best it got. Seoane’s troops had over 65% possession by the break, but couldn’t find a way through the Karlsruhe defence as it remained 1-0 after 45 minutes.
The second half got off to a fast pace. Captain Hradecky had to save a free-kick from Marvin Wanitzek before Karlsruhe skipper Jerome Gondorf got in a crucial block to deny Amiri at the other end. The Werkself finally had their breakthrough after 54 minutes when Jeremie Frimpong played a great one-two with Adli in the box and fired the ball into the top left corner for the equaliser.
Bayer 04 then failed to convert their supremacy into further chances. A lack of accuracy in the final third meant shooting opportunities were at a premium. But the visitors showed they could be clinical and restored the lead with their next chance. Hradecky played a pass straight to the feet of striker Kyoung-Rok Choi, who finished to make it 2-1.
Seoane reacted by sending on Demirbay and Wirtz. The Werkself were even more dominant with their two playmakers on the pitch and launched attack after attack, but ultimately to no avail. Adli and debutant substitute Bravo both fired over from central positions. Leverkusen pushed until the end for an equaliser, but Karlsruhe threw everything they could into blocks and challenges to get their 2-1 win over the line.

Next up for Bayer 04 is another home game against Wolfsburg on Saturday, 30 October in the Bundesliga. Kick-off at the BayArena is at 15:30 CEST.
Stats:
Bayer 04: Hradecky – Frimpong, Tah, Tapsoba, Bakker (Sinkgraven 77') – Palacios (Demirbay 64'), Andrich – Diaby, Amiri (Wirtz 64'), Adli – Paulinho (Bravo 77')
Karlsruhe: Gersbeck – Thiede, Gordon, Kobald, Heise (Jakob 86') – Breithaupt (Batmaz 81') – Choi, Wanitzek, Gondorf, Cueto (Lorenz 66') – Hofmann (Schleusener 81')
Goals: 0-1 Cueto (4'), 1-1 Frimpong (54'), 1-2 Choi (64')
Yellow cards: Frimpong, Tah – Gordon
Referee: Tobias Welz (Wiesbaden)
Attendance: 13,060

Edmond Tapsoba has signed an early extension to his contract with Bayer 04 Leverkusen. With two years left on his current deal, the 27-year-old Burkina Faso international has extended his contract until 30 June 2031. The centre-back joined as a young talent from Portuguese top-flight club Vitoria Guimaraes at the start of 2020.
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A special surprise: during the preview for the 'Fierté Burkinabè' documentary about Edmond Tapsoba, Bayer 04 directors Fernando Carro and Simon Rolfes announced Tapsoba's contract extension until 2031 together with the centre-back. He then spoke to Werkself-TV about his time in Leverkusen so far and future ambitions...
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This evening was deeply moving: At a really special setting, Bayer 04 exclusively presented the specially produced documentary ‘Fierté Burkinabè’ ("Burkinabe Pride") about Edmond Tapsoba on Tuesday. For the preview at the BayArena, the parents of the Werkself player and other close companions travelled all the way from his African homeland Burkina Faso. The 45-minute film shows Tapsoba's extraordinary career from his beginnings in Ouagadougou to Leverkusen as well as the work of his foundation "Fondation Edmond Tapsoba", with representatives from Burkina Faso also present. Fans can watch the documentary free of charge on Werkself TV and YouTube from Wednesday night at 20:00 CEST.
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Bayer 04 have signed left-back Carolin Simon from champions Bayern Munich for the coming season. The 33-year-old former Germany international, who played for Leverkusen from 2013 to 2016, has signed a contract to 30 June 2028.
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Bayer 04 Women have strengthened for the coming season with the signing of Lobke Loone. The 23-year-old Dutch striker joins from Utrecht on a contract until 30 June 2028.
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