The well-earned point in the Europa League away game at Real Betis (1-1) was followed by last Sunday’s 2-2 draw at FC Köln, which for Gerardo Seoane "felt like a defeat. The team was obviously disappointed and frustrated," added the 42-year-old. But they've shown before, as after the 5-1 defeat against Bayern Munich, "that they can quickly recover and are ready to carry on learning."
The Swiss boss is in good spirits going into the knockout encounter with Karlsruher SC, who are currently eighth in Bundesliga 2. "We want to go through to the next round, have the right attitude on the pitch, show a response and keep on developing," said Seoane at the press conference on Tuesday afternoon.
The stats are in favour of the Black and Reds: Amongst the teams who Bayer 04 have played at least ten times since the Bundesliga was founded, the number of defeats is only better against FC Augsburg (0%) than it is against KSC (14%). The only previous cup clash with the team from South Germany in August 2017 saw the Werkself go through with a 3-0 victory after extra time. Back then, Dominik Kohr, Joel Pohjanpalo and Leon Bailey scored in the pouring rain at the Wildparkstadion.
At that time still in the third division, Karlsruhe developed into a solid second division side last season – above all thanks to head coach and former KSC player Christian Eichner. "They have picked up important away wins. They have a good mix of experienced and young players with good physiques," reported Seoane, who has taken a close look at the opponents with his fellow coaches. “They definitely have weapons, for example impressive set-pieces. But if we produce a good performance then we have a chance of going through to the next round."
Bayer 04 were hit by two setbacks yesterday: Karim Bellarabi suffered a muscle injury in his thigh in Cologne and Patrik Schick a torn ligament in his ankle. The two forwards will probably only be available again after the international break in the middle of November.
Lucas Alario could now get more time on the pitch up front. The Argentina international scored 11 goals in the last Bundesliga campaign. After his start in Seville last week, the 29-year-old has complained of slight muscle problems that meant he was only able to complete parts of full training on Tuesday. "I'm waiting for the feedback from the doctors and physios and then I'll consider the risks. There are still four games to go to the international break and we will always need Lucas given that Schick is ruled out," explained Seoane.
U19 striker Iker Bravo could be in the senior squad for the first time against Karlsruhe. "The idea is in the room," said Seoane who welcomed the Spaniard to the training ground on Tuesday.
The 16-year-old Bravo joined Leverkusen in the summer from the world-renowned La Masia academy at Barcelona. Last weekend, the U19 player netted a brace in the 3-1 win in the U19 Bundesliga match against Fortuna Düsseldorf. That included a notable goal scored an impressive goal scored with an overhead kick.
Match information:
Broadcasters: Sky and Werkself Radio
Referee: Tobias Welz (Wiesbaden)

Calling all Werkself fans: Even during the three-week international break – a first for September and October – you have the chance to visit the BayArena – and for a very special occasion. Bayer 04 is hosting a Health Day on Saturday 3 October, from 10:00 to 14:00 CEST in the Premium Lounge. Together with Bayer Vital and main sponsor BarmeniaGothaer, the Bundesliga club invites you to an interactive, free event centred on the theme of health. Partners will be present on site with their own exciting activities. Here is an overview of the programme of events.
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Werkself-TV shows the highlights of Bayer 04 Women's 2-1 win at SC Freiburg on Matchday 5 of the 2026/27 Google Pixel Women's Bundesliga.
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Bayer 04 produced an impressive display from start to finish as they maintained their perfect home record this season with a 2-0 win over RB Leipzig on Bundesliga Matchday 4. Patrik Schick opened the scoring just before half-time, with Miguel Gutiérrez getting his first Werkself goal to wrap up the three points at the BayArena, where fans also got to enjoy the family matchday activities.
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Peter Hermann passed away on Saturday at the age of 74. The entire Bayer 04 family is deeply saddened by the loss of a much-loved figure who helped shape football in Leverkusen over many decades. He was also one of the most respected coaches in the whole of Germany. Hermann had been suffering from ALS (amyotrophic lateral sclerosis) for some time.
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