The well-earned point in the Europa League away game at Real Betis (1-1) was followed by last Sunday’s 2-2 draw at FC Köln, which for Gerardo Seoane "felt like a defeat. The team was obviously disappointed and frustrated," added the 42-year-old. But they've shown before, as after the 5-1 defeat against Bayern Munich, "that they can quickly recover and are ready to carry on learning."
The Swiss boss is in good spirits going into the knockout encounter with Karlsruher SC, who are currently eighth in Bundesliga 2. "We want to go through to the next round, have the right attitude on the pitch, show a response and keep on developing," said Seoane at the press conference on Tuesday afternoon.
The stats are in favour of the Black and Reds: Amongst the teams who Bayer 04 have played at least ten times since the Bundesliga was founded, the number of defeats is only better against FC Augsburg (0%) than it is against KSC (14%). The only previous cup clash with the team from South Germany in August 2017 saw the Werkself go through with a 3-0 victory after extra time. Back then, Dominik Kohr, Joel Pohjanpalo and Leon Bailey scored in the pouring rain at the Wildparkstadion.
At that time still in the third division, Karlsruhe developed into a solid second division side last season – above all thanks to head coach and former KSC player Christian Eichner. "They have picked up important away wins. They have a good mix of experienced and young players with good physiques," reported Seoane, who has taken a close look at the opponents with his fellow coaches. “They definitely have weapons, for example impressive set-pieces. But if we produce a good performance then we have a chance of going through to the next round."
Bayer 04 were hit by two setbacks yesterday: Karim Bellarabi suffered a muscle injury in his thigh in Cologne and Patrik Schick a torn ligament in his ankle. The two forwards will probably only be available again after the international break in the middle of November.
Lucas Alario could now get more time on the pitch up front. The Argentina international scored 11 goals in the last Bundesliga campaign. After his start in Seville last week, the 29-year-old has complained of slight muscle problems that meant he was only able to complete parts of full training on Tuesday. "I'm waiting for the feedback from the doctors and physios and then I'll consider the risks. There are still four games to go to the international break and we will always need Lucas given that Schick is ruled out," explained Seoane.
U19 striker Iker Bravo could be in the senior squad for the first time against Karlsruhe. "The idea is in the room," said Seoane who welcomed the Spaniard to the training ground on Tuesday.
The 16-year-old Bravo joined Leverkusen in the summer from the world-renowned La Masia academy at Barcelona. Last weekend, the U19 player netted a brace in the 3-1 win in the U19 Bundesliga match against Fortuna Düsseldorf. That included a notable goal scored an impressive goal scored with an overhead kick.
Match information:
Broadcasters: Sky and Werkself Radio
Referee: Tobias Welz (Wiesbaden)

A fresh look for the BayArena: The Bayer 04 stadium will have new seating in the form of folding seats for the 2026/27 campaign that will ensure significantly improved seating comfort and simplified movement within the rows of seats. As part of routine replacement after 17 years, fans of the Werkself were able to purchase the existing seats, used to witness the first German league title in the club's history. In addition, a large proportion of the seats will be donated to charitable projects, primarily in the local region. Bayer 04 fans can look forward to new, functional folding seats for the season opener at the beginning of August - still in the club colours of black and red, of course. A glimpse at the BayArena during the refurbishment.
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On Monday evening, 8 June, around 250 people came to the Bürgerhaus Baumberg at the invitation of Bayer 04 to find out details of the new plans for the campus on Alfred-Nobel-Straße at an information event. More compact, greener and with many advantages for Monheim am Rhein - those are the aims. There were lively discussions for around three hours and some misunderstandings were cleared up.
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Werkself player Montrell Culbreath and Bayer 04 loanee Francis Onyeka are part of Germany's final squad for the U19 European Championships this summer. The tournament is in Wales from 24 June to 12 July.
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When Malik Tillman arrived at Bayer 04 Leverkusen from PSV Eindhoven last summer, he did more than just add attacking midfield strength to the team — he reconnected the club with a unique and understated American lineage that stretches back more than three decades.
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Bayer 04 are away to third-division club SV Wehen Wiesbaden in the first round of the 2026/27 DFB Pokal. That was the outcome of the draw on Saturday night, 6 June, at the German Football Museum in Dortmund. The Werkself first round tie will be played between 21 and 24 August. The exact date has yet to be finalised.
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