The well-earned point in the Europa League away game at Real Betis (1-1) was followed by last Sunday’s 2-2 draw at FC Köln, which for Gerardo Seoane "felt like a defeat. The team was obviously disappointed and frustrated," added the 42-year-old. But they've shown before, as after the 5-1 defeat against Bayern Munich, "that they can quickly recover and are ready to carry on learning."
The Swiss boss is in good spirits going into the knockout encounter with Karlsruher SC, who are currently eighth in Bundesliga 2. "We want to go through to the next round, have the right attitude on the pitch, show a response and keep on developing," said Seoane at the press conference on Tuesday afternoon.
The stats are in favour of the Black and Reds: Amongst the teams who Bayer 04 have played at least ten times since the Bundesliga was founded, the number of defeats is only better against FC Augsburg (0%) than it is against KSC (14%). The only previous cup clash with the team from South Germany in August 2017 saw the Werkself go through with a 3-0 victory after extra time. Back then, Dominik Kohr, Joel Pohjanpalo and Leon Bailey scored in the pouring rain at the Wildparkstadion.
At that time still in the third division, Karlsruhe developed into a solid second division side last season – above all thanks to head coach and former KSC player Christian Eichner. "They have picked up important away wins. They have a good mix of experienced and young players with good physiques," reported Seoane, who has taken a close look at the opponents with his fellow coaches. “They definitely have weapons, for example impressive set-pieces. But if we produce a good performance then we have a chance of going through to the next round."
Bayer 04 were hit by two setbacks yesterday: Karim Bellarabi suffered a muscle injury in his thigh in Cologne and Patrik Schick a torn ligament in his ankle. The two forwards will probably only be available again after the international break in the middle of November.
Lucas Alario could now get more time on the pitch up front. The Argentina international scored 11 goals in the last Bundesliga campaign. After his start in Seville last week, the 29-year-old has complained of slight muscle problems that meant he was only able to complete parts of full training on Tuesday. "I'm waiting for the feedback from the doctors and physios and then I'll consider the risks. There are still four games to go to the international break and we will always need Lucas given that Schick is ruled out," explained Seoane.
U19 striker Iker Bravo could be in the senior squad for the first time against Karlsruhe. "The idea is in the room," said Seoane who welcomed the Spaniard to the training ground on Tuesday.
The 16-year-old Bravo joined Leverkusen in the summer from the world-renowned La Masia academy at Barcelona. Last weekend, the U19 player netted a brace in the 3-1 win in the U19 Bundesliga match against Fortuna Düsseldorf. That included a notable goal scored an impressive goal scored with an overhead kick.
Match information:
Broadcasters: Sky and Werkself Radio
Referee: Tobias Welz (Wiesbaden)

Following the international break, the Bayer 04 women’s team face their next head-to-head clash in the race for a top spot in the Bundesliga. In Saturday’s home match (14:00 CEST), the fourth-placed side host third-placed Eintracht Frankfurt at the Ulrich Haberland Stadium. Head coach Roberto Pätzold is well aware of the great opportunity this presents for his team.
Show more
Bayer 04 make their first trip to Poland for over 30 years as they face Lech Poznan on Matchday 2 of the league phase in the 2026/27 UEFA Europa League. The game kicks off at 18:45 CEST on Thursday, but the team will be preparing for the action on Wednesday with training, travel and pre-match press conferences. We’ll bring you all the latest news here…
Show more
Bayer 04 remain unbeaten in the 2026/27 UEFA Europa League. After winning the opener against NK Celje, the Werkself followed that up on Thursday night with a 4–0 win away at the Polish champions Lech Poznan. Patrik Schick, who came on as a substitute early in the game, scored twice from the penalty spot, and Malik Tillman also found the back of the net before half-time. The second half was a more subdued affair, with Ibrahim Maza scoring late on to seal the final 4-0 scoreline.
Show more
Since 2023, Bayer 04 has been organising regular free goalkeeping coach training sessions at the BayArena. As in previous years, the event attracted enormous interest in mid-October 2026. Around 140 participants – mostly goalkeeping coaches from the region, but also team and academy coaches as well as association staff – came to the Werkself stadium to gain expert knowledge on the subject of zonal marking. Through a theoretical keynote presentation and a practical session on the pitch, the participants gained insights into goalkeeping and goalkeeper training at Bayer 04.
Show more