The well-earned point in the Europa League away game at Real Betis (1-1) was followed by last Sunday’s 2-2 draw at FC Köln, which for Gerardo Seoane "felt like a defeat. The team was obviously disappointed and frustrated," added the 42-year-old. But they've shown before, as after the 5-1 defeat against Bayern Munich, "that they can quickly recover and are ready to carry on learning."
The Swiss boss is in good spirits going into the knockout encounter with Karlsruher SC, who are currently eighth in Bundesliga 2. "We want to go through to the next round, have the right attitude on the pitch, show a response and keep on developing," said Seoane at the press conference on Tuesday afternoon.
The stats are in favour of the Black and Reds: Amongst the teams who Bayer 04 have played at least ten times since the Bundesliga was founded, the number of defeats is only better against FC Augsburg (0%) than it is against KSC (14%). The only previous cup clash with the team from South Germany in August 2017 saw the Werkself go through with a 3-0 victory after extra time. Back then, Dominik Kohr, Joel Pohjanpalo and Leon Bailey scored in the pouring rain at the Wildparkstadion.
At that time still in the third division, Karlsruhe developed into a solid second division side last season – above all thanks to head coach and former KSC player Christian Eichner. "They have picked up important away wins. They have a good mix of experienced and young players with good physiques," reported Seoane, who has taken a close look at the opponents with his fellow coaches. “They definitely have weapons, for example impressive set-pieces. But if we produce a good performance then we have a chance of going through to the next round."
Bayer 04 were hit by two setbacks yesterday: Karim Bellarabi suffered a muscle injury in his thigh in Cologne and Patrik Schick a torn ligament in his ankle. The two forwards will probably only be available again after the international break in the middle of November.
Lucas Alario could now get more time on the pitch up front. The Argentina international scored 11 goals in the last Bundesliga campaign. After his start in Seville last week, the 29-year-old has complained of slight muscle problems that meant he was only able to complete parts of full training on Tuesday. "I'm waiting for the feedback from the doctors and physios and then I'll consider the risks. There are still four games to go to the international break and we will always need Lucas given that Schick is ruled out," explained Seoane.
U19 striker Iker Bravo could be in the senior squad for the first time against Karlsruhe. "The idea is in the room," said Seoane who welcomed the Spaniard to the training ground on Tuesday.
The 16-year-old Bravo joined Leverkusen in the summer from the world-renowned La Masia academy at Barcelona. Last weekend, the U19 player netted a brace in the 3-1 win in the U19 Bundesliga match against Fortuna Düsseldorf. That included a notable goal scored an impressive goal scored with an overhead kick.
Match information:
Broadcasters: Sky and Werkself Radio
Referee: Tobias Welz (Wiesbaden)

Werkself player Montrell Culbreath and Bayer 04 loanee Francis Onyeka are part of Germany's final squad for the U19 European Championships this summer. The tournament is in Wales from 24 June to 12 July.
Show more
Carles Martìnez is raring to go. The 42-year-old speaks in his first interview in Leverkusen about the club's development to date and how he wants to build on it. He describes his previous work in France, Kuwait, Qatar and his native Barcelona, his experience in developing young players, and the key steps between now and the start of pre-season training.
Show more
New Bayer 04 head coach Carles Martínez has arrived in Leverkusen! At midday on Friday, the 42-year-old spoke in a press conference at the BayArena about his philosophy and his aims. Managing director sport Simon Rolfes also discussed the reasons for appointing the former Toulouse boss.
Show more
Bayer 04 Leverkusen have appointed Carles Martínez Novell as the new head coach. The 42-year-old Spaniard worked for FC Toulouse in the French Ligue 1 until the end of the season. Martínez finished last term in ninth place with the club from the south of France. He will take over the Werkself on 1 July 2026 and has signed a contract to 30 June 2028. Martínez, whose contract with Toulouse expires at the end of the month, succeeds Kasper Hjulmand at Leverkusen, who is leaving the club after one season.
Show more
Welcome to Leverkusen, Carles Martínez Novell. Bayer 04 have appointed the 42-year-old Spaniard as the new head coach on a contract to 2028. Martínez most recently worked for FC Toulouse in the French Ligue 1 until the end of the season. He previously spent four years at Barcelona's legendary academy La Masia in his home city. Bayer04.de introduces Martínez in more detail.
Show more