
Three matches, seven points, top spot. That is the almost perfect record for Bayer 04 from the first three games in the current Europa League campaign. The team under head coach Gerardo Seoane are still unbeaten on the European stage – as are Real Betis: The Green and Whites have the same number of points from the first three games but are behind the Werkself due to an inferior goal difference (8:5) compared with the Werkself (7:2).
There are 14 days between the previous and the forthcoming meetings of the two clubs. Striker Borja Iglesias gave Manuel Pellegrini's team the lead from the penalty spot on 75 minutes in the 1-1 draw. Bayer 04 levelled seven minutes later through Robert Andrich. With almost the last kick of the game, Kerem Demirbay had the chance to make it 2-1 but his shot from ten yards was kept out with an impressive reaction save from the Betis goalkeeper Claudio Bravo.
The Andalusian side have played three matches in La Liga since the Europa League clash at the Stadio Benito Villamarin. Immediately after the draw with the Seoane team, Nabil Fekir and Co. overcame Rayo Vallecano with a 3-2 victory in an exciting game at home and that was followed with a convincing 4-1 victory over Valencia in the third home game in succession.
However, Real Betis suffered a defeat on the road last time out: Atlético Madrid were the 3-0 winners last Sunday. Nevertheless, the Green and Whites have moved up three places to fifth place in Spain's top-flight since the last Europa League match against Bayer 04 – their current tally in the league is 21 points from 12 games.
While the Werkself head coach Gerardo Seoane has another player sidelined in Mitchel Bakker (ankle injury), his opposite number Pellegrini has a full squad to choose from for the match at the BayArena.
The Chilean is well known as a fan of rotation: Midfielder Nabil Fekir and striker Borja Iglesias were both on the bench against Atlético. The latter came on as substitute in the closing stages but Fekir did not play.
It is possible the two key players in the Betis attacking game could return to the starting line-up on Thursday. Jonathan Tah and Co. will again have to keep a wary eye on the duo as Fekir and Iglesias have already been involved in eleven goals this season.

Video game developer Electronic Arts (EA), in collaboration with the Bundesliga, has announced the six nominees for the Bundesliga Player of the Month award for October 2026 – and Bayer 04’s Ibrahim Maza is among them. Fans of the Black and Reds can vote from now until Sunday 8 November (23:59 CET).
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On Tuesday night, the Leverkusen e-sports team played the first three of their six group stage matches in the second round of the 2026/27 VBL Club Championship. They were unable to secure more than a draw in either of their matches against FC Augsburg and VfB Stuttgart. The match against Bayern Munich ended in defeat.
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Once again, several Werkself players are set to represent their respective national teams during the final international break of the calendar year. Here is an overview of the Leverkusen players called up for international duty and the match dates. This will be updated regularly.
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The Bundesliga has announced the nominees for the ‘Top Goal of the Month’ award for October. Fans of the Werkself can now vote for, amongst others, Robert Andrich’s stunning volley from the match against Mainz 05 or Moussa Diaby’s curling shot into the top corner from the same fixture. Voting, exclusively on the Bundesliga app, remains open until Sunday, 8 November (23:59 CET).
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