
Including qualification rounds, the Werkself have advanced the last 13 times when they've won the first leg by a margin of two goals or more. However, West Ham have won their last 11 European games on home soil - seven of them by a two-goal difference, which they'll need again tonight to knock out Bayer 04. The Hammers will certainly draw confidence from the fact they've won three of their last four home encounters with teams from Germany, while the Werkself have only triumphed on one of their last 10 visits to England.
Last year's UEFA Europa Conference League winners must do without a couple of key players tonight, though. Attacker Lucas Paquetá and full-back Emerson are both suspended after being booked in the first leg. It remains to be seen whether top scorer Jarrod Bowen will be fit - the forward missed the first leg due to a back problem.
Last weekend could have hardly turned out more different for both clubs. While the Werkself clinched the first Bundesliga title in the club's history with a 5-0 victory over SV Werder Bremen, West Ham suffered a blow in the Premier League. For the first time in 23 years, the Hammers lost a London derby at home to Fulham, losing 2-0 to the side in 12th place. At full time, manager David Moyes summarised: "I'm really disappointed." The 60-year-old Scot then quickly turned his attention towards today's second leg: "We will get ready for the game on Thursday night now, and hopefully we can respond in the right way.." Goalkeeper Lukas Fabianski, who faced 33 shots on his goal against Leverkusen last week, said after the game against Fulham: "We have a really good record at home in European competitions, so let's see what happens." There's more on the Hammers in our opposition profile.
Spanish referee José María Sánchez has been appointed by UEFA for the clash at the London Stadium. The 40-year-old will be assisted by compatriots Raúl Cabañero and Iñigo Prieto, with Carlos del Cerro Grande as the VAR.

The NB Vintage Collection is here and available now! Members enjoy an exclusive priority purchase period (online shop only). Non-members will then be able to purchase items from Saturday 17 October (10:00 CEST). Sales will also begin at the same time at the Bayer 04 Fanwelt.
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Intercultural exchange: a youth team from Ouagadougou, the capital city of Burkina Faso, visited Leverkusen in the last few days. The players and staff from AD DUHA FC enjoyed a varied programme including training, a friendly - and a very special experience on Saturday afternoon.
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The new eSports season is just around the corner. The VBL Club Championship by WOW starts on Thursday 15 October (from 18:00 CEST). And, as every year, here’s an overview: What changes are there? What is staying the same?
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Bayer 04 record-appearance maker Rüdiger Vollborn invites you to another evening in the popular ‘Rudi lädt ein’ series: on Tuesday 10 November, in collaboration with Bayer AG, the focus will be on the Nazi period. The focus will be on football, Bayer 04 and the city of Leverkusen.
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