
Lukas Hradecky and Co. will find out the next hurdle on the European stage on Friday afternoon 25 February. The draw for the Round of 16 will be made at the UEFA headquarters in Nyon from noon CET. The group winners in the Europa League, alongside Bayer 04 including Bundesliga rivals Eintracht Frankfurt, are drawn in pot one. Pot two has the winners of the play-off round, all the runners-up in the Europa League and teams finishing third in the Champions League groups. In addition to RB Leipzig and Real Betis there are the following seven clubs.
The Werkself could face an opponent from the group stage in the current Europa League campaign in the shape of Real Betis. The runners-up in Group G, who had three points less than the Black and Reds, beat the Russian champions Zenit St Petersburg in the play-offs (3-2, 0-0). The team under head coach Gerardo Seoane drew 1-1 away to the team currently third in La Liga and that was followed by a convincing 4-0 victory at home.
Bayer 04 played Rangers the season before – also in the Round of 16. Leverkusen won 3-1 at Ibrox and that was followed by a 1-0 win at the BayArena. The team currently lying second in Scotland's top flight secured a surprise win against Dortmund in the play-offs (4-2, 2-2).
To be fair, FC Barcelona sounds more like the Champions League rather than the Europa league. However, the top club from Spain only finished third behind Bayern Munich and Benfica in their Champions League group. In the Round of 32 there was a 1-1 draw in the first leg against Napoli that was followed by a 4-2 victory in Italy. The last game between the Werkself and the Catalan side was back on 9 December 2015 – a 1-1 draw at Leverkusen.
Bayer 04 could also draw Sevilla. The record Europa League winners (four titles since 2014) also dropped down from the Champions League. Thanks to a 3-1 in the first leg of the play-offs against Dynamo Zagreb, the 1-0 defeat in the second leg against the top Croatian side did not affect the outcome of the tie.
The Portuguese league is always ranked behind the top five leagues in UEFA's five-year assessment. The following four top clubs are the normal representatives on the European stage: Benfica, Sporting Club, FC Porto and Sporting Braga. The Werkself can face the latter two clubs in the Round of 16. Porto beat Lazio (2-1, 2-2), Braga overcame the surprise team Sheriff Tiraspol (2-0, 3-2 on penalties).
Atalanta are well-known to the majority of football clubs in Europe from previous years. However, the Werkself have never played the club from northern Italy. Atalanta finished third in their Champions League group and then made progress through the Europa League play-off round against Olympiakos (2-1, 3-0).
The Europa League Round of 16 first leg matches will be played on Thursday 10 March with the second legs a week later on 17 March. Bayer 04 are away first.

A group of about 50 members of the Bayer 04 Football Academy São Paulo visited Leverkusen over the past few days, accompanied by Bayer 04 club legend Paulo Sergio and Luiz Felipe (managing director of academy in São Paulo) for a week full of football, encounters and very special insights. In addition to the Bundesliga away game in Elversberg and the home game against Union Berlin, the visit also featured a joint training session with the Bayer 04 Football Academy in Leverkusen and a tour of the Bayer AG facilities. The guests also gained special insights into the club and the world of Bayer 04.
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The men's clothing retailer LERROS will remain the official fashion and premium partner of Bayer 04 for the current season. As in the past, LERROS will provide the club's men's team, coaching staff and management with high-quality clothing for international trips.
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“Diaby! Diaby! Diaby!” was the cry around the BayArena as the Werkself danced in front of the north stand following their 4-0 win over Union Berlin. Captain Edmond Tapsoba gave his new (and old) teammate a friendly shove forward to take in the acclaim from the fans. The returning Frenchman was typically reserved in thanking the supporters but was clearly emotional about what was happening.
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Bayer 04 produced a dominant and impressive 4-0 win over Union Berlin as they picked up three points in their first home game of the 2026/27 Bundesliga campaign. Exequiel Fernández opened the scoring after only 41 seconds, with Facundo Medina doubling the lead before the half-hour mark. Patrik Schick and Ibrahim Maza continued the procession in the second period, in which Moussa Diaby came on for his first Leverkusen appearance for over three years.
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