
Lukas Hradecky and Co. will find out the next hurdle on the European stage on Friday afternoon 25 February. The draw for the Round of 16 will be made at the UEFA headquarters in Nyon from noon CET. The group winners in the Europa League, alongside Bayer 04 including Bundesliga rivals Eintracht Frankfurt, are drawn in pot one. Pot two has the winners of the play-off round, all the runners-up in the Europa League and teams finishing third in the Champions League groups. In addition to RB Leipzig and Real Betis there are the following seven clubs.
The Werkself could face an opponent from the group stage in the current Europa League campaign in the shape of Real Betis. The runners-up in Group G, who had three points less than the Black and Reds, beat the Russian champions Zenit St Petersburg in the play-offs (3-2, 0-0). The team under head coach Gerardo Seoane drew 1-1 away to the team currently third in La Liga and that was followed by a convincing 4-0 victory at home.
Bayer 04 played Rangers the season before – also in the Round of 16. Leverkusen won 3-1 at Ibrox and that was followed by a 1-0 win at the BayArena. The team currently lying second in Scotland's top flight secured a surprise win against Dortmund in the play-offs (4-2, 2-2).
To be fair, FC Barcelona sounds more like the Champions League rather than the Europa league. However, the top club from Spain only finished third behind Bayern Munich and Benfica in their Champions League group. In the Round of 32 there was a 1-1 draw in the first leg against Napoli that was followed by a 4-2 victory in Italy. The last game between the Werkself and the Catalan side was back on 9 December 2015 – a 1-1 draw at Leverkusen.
Bayer 04 could also draw Sevilla. The record Europa League winners (four titles since 2014) also dropped down from the Champions League. Thanks to a 3-1 in the first leg of the play-offs against Dynamo Zagreb, the 1-0 defeat in the second leg against the top Croatian side did not affect the outcome of the tie.
The Portuguese league is always ranked behind the top five leagues in UEFA's five-year assessment. The following four top clubs are the normal representatives on the European stage: Benfica, Sporting Club, FC Porto and Sporting Braga. The Werkself can face the latter two clubs in the Round of 16. Porto beat Lazio (2-1, 2-2), Braga overcame the surprise team Sheriff Tiraspol (2-0, 3-2 on penalties).
Atalanta are well-known to the majority of football clubs in Europe from previous years. However, the Werkself have never played the club from northern Italy. Atalanta finished third in their Champions League group and then made progress through the Europa League play-off round against Olympiakos (2-1, 3-0).
The Europa League Round of 16 first leg matches will be played on Thursday 10 March with the second legs a week later on 17 March. Bayer 04 are away first.

Werkself player Montrell Culbreath and Bayer 04 loanee Francis Onyeka are part of Germany's final squad for the U19 European Championships this summer. The tournament is in Wales from 24 June to 12 July.
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New Bayer 04 head coach Carles Martínez has arrived in Leverkusen! At midday on Friday, the 42-year-old spoke in a press conference at the BayArena about his philosophy and his aims. Managing director sport Simon Rolfes also discussed the reasons for appointing the former Toulouse boss.
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Bayer 04 Leverkusen have appointed Carles Martínez Novell as the new head coach. The 42-year-old Spaniard worked for FC Toulouse in the French Ligue 1 until the end of the season. Martínez finished last term in ninth place with the club from the south of France. He will take over the Werkself on 1 July 2026 and has signed a contract to 30 June 2028. Martínez, whose contract with Toulouse expires at the end of the month, succeeds Kasper Hjulmand at Leverkusen, who is leaving the club after one season.
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Welcome to Leverkusen, Carles Martínez Novell. Bayer 04 have appointed the 42-year-old Spaniard as the new head coach on a contract to 2028. Martínez most recently worked for FC Toulouse in the French Ligue 1 until the end of the season. He previously spent four years at Barcelona's legendary academy La Masia in his home city. Bayer04.de introduces Martínez in more detail.
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Bayer 04 plans for the 2026/27 pre-season continue to take shape. The Werkself will kick off the new season in mid-July with the return to the training ground. The highlight will be the official season opener on 8 August at the BayArena, including a friendly against La Liga club Sevilla. Friendlies in Germany will take the team to neighbouring Monheim, Offenbach and Jena.
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