
Lukas Hradecky and Co. will find out the next hurdle on the European stage on Friday afternoon 25 February. The draw for the Round of 16 will be made at the UEFA headquarters in Nyon from noon CET. The group winners in the Europa League, alongside Bayer 04 including Bundesliga rivals Eintracht Frankfurt, are drawn in pot one. Pot two has the winners of the play-off round, all the runners-up in the Europa League and teams finishing third in the Champions League groups. In addition to RB Leipzig and Real Betis there are the following seven clubs.
The Werkself could face an opponent from the group stage in the current Europa League campaign in the shape of Real Betis. The runners-up in Group G, who had three points less than the Black and Reds, beat the Russian champions Zenit St Petersburg in the play-offs (3-2, 0-0). The team under head coach Gerardo Seoane drew 1-1 away to the team currently third in La Liga and that was followed by a convincing 4-0 victory at home.
Bayer 04 played Rangers the season before – also in the Round of 16. Leverkusen won 3-1 at Ibrox and that was followed by a 1-0 win at the BayArena. The team currently lying second in Scotland's top flight secured a surprise win against Dortmund in the play-offs (4-2, 2-2).
To be fair, FC Barcelona sounds more like the Champions League rather than the Europa league. However, the top club from Spain only finished third behind Bayern Munich and Benfica in their Champions League group. In the Round of 32 there was a 1-1 draw in the first leg against Napoli that was followed by a 4-2 victory in Italy. The last game between the Werkself and the Catalan side was back on 9 December 2015 – a 1-1 draw at Leverkusen.
Bayer 04 could also draw Sevilla. The record Europa League winners (four titles since 2014) also dropped down from the Champions League. Thanks to a 3-1 in the first leg of the play-offs against Dynamo Zagreb, the 1-0 defeat in the second leg against the top Croatian side did not affect the outcome of the tie.
The Portuguese league is always ranked behind the top five leagues in UEFA's five-year assessment. The following four top clubs are the normal representatives on the European stage: Benfica, Sporting Club, FC Porto and Sporting Braga. The Werkself can face the latter two clubs in the Round of 16. Porto beat Lazio (2-1, 2-2), Braga overcame the surprise team Sheriff Tiraspol (2-0, 3-2 on penalties).
Atalanta are well-known to the majority of football clubs in Europe from previous years. However, the Werkself have never played the club from northern Italy. Atalanta finished third in their Champions League group and then made progress through the Europa League play-off round against Olympiakos (2-1, 3-0).
The Europa League Round of 16 first leg matches will be played on Thursday 10 March with the second legs a week later on 17 March. Bayer 04 are away first.

Bayer 04 Leverkusen will to have manage without forward Eliesse Ben Seghir. The Morocco international suffered a ligament injury in his left ankle before the AFCON final defeat against Senegal (0-1 a.e.t.).
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The VBL Club Championship 2025/26 continues. Tonight, 27 January (live on Twitch and on the Bayer 04 app from 18:00 CET), the Leverkusen eSports team will play the remaining three matches in the online preliminary round of Showdown Four. They are up against FC Kaiserslautern, SC Freiburg and the current club champions and Showdown Three winners RB Leipzig, with whom Bayer 04, club runners-up and Showdown One winners, shared some memorable moments, especially last year. The lowdown on our next opponents.
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Welcome to Leverkusen, Jonas Omlin. Bayer 04 have signed the 32-year-old goalkeeper on loan from Bundesliga side Borussia Mönchengladbach until the end of the season. Managing director sport Simon Rolfes described the Swiss shot stopper, signed by the Werkself in reaction to the long-term absence of first choice keeper Mark Flekken, as an "internationally experienced keeper." Bayer04.de takes a closer look at the new signing, who will wear the number 18 jersey.
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Under the motto ‘Sound of Dreams - #aCROSS Europe 2025/26’, Bayer 04 are turning this season's UEFA Champions League season into a festival. In addition to a Spotify playlist that fans can use to get in the mood for the Champions League nights, there is also a tour pass with stickers for the respective UCL matches exclusively for Bayer 04 Club members. These could be picked up in the respective weeks of the matches. The sticker for the final clash in the league phase (Villarreal, 28 January, 21:00 CET) is now available at the Fanwelt. The competition for all diligent sticker collectors is also now open. Read on for further information.
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