
The Bayer 04 v Lotte tie is a repeat of last season's first-round meeting that the Werkself won 3-0 thanks to goals from Kießling, Calhanoglu and Bender.
In this season's first round Bayer 04 won 2-1 at fifth tier SC Hauenstein. Lotte produced a sensational upset in their opening tie against Bundesliga side Werder Bremen. The team, including former Bayer 04 keeper Benedikt Fernandez, were champions of the Regional League West and thereby achieved promotion to division three. Currently they are ninth in the table with five points from four games.
The second round ties will be played on 25 and 26 October. 16 Bundesliga clubs are still in the competition with only RB Leipzig (6-5 defeat on penalties against Dynamo Dresden) and Werder Bremen (21 defeat away to Sportfreunde Lotte) going out in first round. 13 teams from the second division are in the second round plus the two third division outfits Sportfreunde Lotte and Hallescher FC, and Regional League side FC Astoria Walldorf.


As well as previously confirmed departures, Bayer 04 Women will also say goodbye to Vanessa Haim and Shen Menglu before Sunday’s final game of the season at home to Werder Bremen as the pair leave Leverkusen upon the expiration of their contracts.
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Goalkeeper Anne Moll will leave Bayer 04 Leverkusen at the end of the season. The 21-year-old will join second-tier club VfL Bochum 1848 when her contract expires on 30 June.
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This Sunday will see the end of a special era at Bayer 04 Women: Kristin Kögel will play for the Werkself for the last time in the final match of the season at home to SV Werder Bremen. After six years in Leverkusen, the 26-year-old midfielder will take on a new challenge abroad from the summer.
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Ahead of the conclusion to the 2025/26 season with the Werkself and the World Cup with Argentina, Bayer 04 midfielder Exequiel Palacios answered questions from journalists from the Latin America region. In a digital media round, the 27-year-old, who's been in Leverkusen since 2020, spoke about the "great development potential" in the current Werkself squad as well as his World Cup ambitions with the Albiceleste, among other things.
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