The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Calling all Werkself fans: Even during the three-week international break – a first for September and October – you have the chance to visit the BayArena – and for a very special occasion. Bayer 04 is hosting a Health Day on Saturday 3 October, from 10:00 to 14:00 CEST in the Premium Lounge. Together with Bayer Vital and main sponsor BarmeniaGothaer, the Bundesliga club invites you to an interactive, free event centred on the theme of health. Partners will be present on site with their own exciting activities. Here is an overview of the programme of events.
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Werkself-TV shows the highlights of Bayer 04 Women's 2-1 win at SC Freiburg on Matchday 5 of the 2026/27 Google Pixel Women's Bundesliga.
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Bayer 04 produced an impressive display from start to finish as they maintained their perfect home record this season with a 2-0 win over RB Leipzig on Bundesliga Matchday 4. Patrik Schick opened the scoring just before half-time, with Miguel Gutiérrez getting his first Werkself goal to wrap up the three points at the BayArena, where fans also got to enjoy the family matchday activities.
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Peter Hermann passed away on Saturday at the age of 74. The entire Bayer 04 family is deeply saddened by the loss of a much-loved figure who helped shape football in Leverkusen over many decades. He was also one of the most respected coaches in the whole of Germany. Hermann had been suffering from ALS (amyotrophic lateral sclerosis) for some time.
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