
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Werkself-TV shows the highlights of Bayer 04 Women's 0-2 loss at 1. FC Nürnberg on Matchday 8 of the 2026/27 Google Pixel Women's Bundesliga.
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After nine points from their first three away matches of the 2026/27 season, the Bayer 04 Women suffered their first away defeat on Sunday afternoon. The 2-0 defeat away to FC Nürnberg, who were winless before today, represented a setback for coach Roberto Pätzold’s team in the race for the top spots in the Google Pixel Women’s Bundesliga. Fany Pronietz scored both goals (62’, 85’) for the home side.
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After six consecutive wins, the Werkself have hit a rough patch: Bayer 04 lost 3-0 away to TSG Hoffenheim. Andrej Kramaric put the hosts ahead from the penalty spot (79'), with Alexander Prass and Max Moerstedt adding to the tally shortly before full-time (89’/90+5’). After ten matches under Carles Martínez, with the Black and Reds always scoring at least twice, Leverkusen failed to find the net for the first time.
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The Werkself still have a score to settle with TSG Hoffenheim: Bayer 04 lost both matches against the Kraichgau side last term – after the Black and Reds had won all the previous five encounters. Leverkusen are currently on a roll and looking to kick off a new winning streak against TSG in Sinsheim on Sunday 25 October (kick-off: 15:30 CET), and Patrik Schick is keen to continue his current run of form. However, it will not be easy, as coach Christian Ilzer’s team have also gained confidence recently. Today’s matchday news.
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