
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Video game developer Electronic Arts (EA), in collaboration with the Bundesliga, has announced the six nominees for the Bundesliga Player of the Month award for October 2026 – and Bayer 04’s Ibrahim Maza is among them. Fans of the Black and Reds can vote from now until Sunday 8 November (23:59 CET).
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On Tuesday night, the Leverkusen e-sports team played the first three of their six group stage matches in the second round of the 2026/27 VBL Club Championship. They were unable to secure more than a draw in either of their matches against FC Augsburg and VfB Stuttgart. The match against Bayern Munich ended in defeat.
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Once again, several Werkself players are set to represent their respective national teams during the final international break of the calendar year. Here is an overview of the Leverkusen players called up for international duty and the match dates. This will be updated regularly.
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The Bundesliga has announced the nominees for the ‘Top Goal of the Month’ award for October. Fans of the Werkself can now vote for, amongst others, Robert Andrich’s stunning volley from the match against Mainz 05 or Moussa Diaby’s curling shot into the top corner from the same fixture. Voting, exclusively on the Bundesliga app, remains open until Sunday, 8 November (23:59 CET).
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