
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Werkself-TV shows the highlights of the Bayer 04 women's 1-2 loss against VfL Wolfsburg on the 2nd matchday of the Google Pixel Women's Bundesliga 2026/27.
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Bayer 04’s eight opponents in the group stage of the 2026/27 UEFA Europa League have been confirmed. At the draw on Friday 28 August held at the Grimaldi Forum in Monaco, the Werkself were drawn against two opponents from each of the four pots. There are a total of four home and four away matches. Read on for details of opponents and fixture dates.
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In the 3-2 defeat at Bundesliga newcomers SV 07 Elversberg, the Werkself found the back of the net in the closing stages and, with a bit of luck, could still have equalised. “Today, our play wasn’t good enough, particularly when it came to the basics,” said head coach Carles Martínez. Like the boss, Ibrahim Maza also wants to learn from the match and look ahead: “Next week, people should be able to see from the very first minute that we want it more than our opponents.” The Werkself review on the Bundesliga opener in 2026/27.
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Werkself TV shows the highlights of Bayer 04's 2-3 loss at SV 07 Elversberg on Matchday 1 of the 2026/27 Bundesliga season...
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No points to start the league campaign: Bayer 04 lost 3-2 away to newly promoted SV 07 Elversberg in the first Bundesliga match of the 2026/27 campaign. Two quick-fire goals from Lukas Petkov (8’) and Cole Campbell (10’) gave the hosts an early lead, before David Mokwa scored the Saarland side’s third shortly after half-time (46’). In the closing stages, the Werkself rallied and staged a late comeback with goals from Patrik Schick (77’) and Christian Kofane (90+1’), but the Black and Reds were denied an equaliser.
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