
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Bayer 04 Leverkusen have loaned U19 midfielder Jeremiah Mensah to Dutch second-tier side Roda JC Kerkrade for one year. The 18-year-old Germany youth international has a long-term contract at the club to 2031.
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Bayer 04 kick off the final phase of their 2026/27 pre-season preparations with a friendly against Premier League club Nottingham Forest. Head coach Carles Martínez’s team will take to the pitch at the City Ground today, Wednesday 12 August (kick-off: 8.45 pm/7.45 pm local time). Werkself-TV will broadcast the match live and in full exclusively for Bayer 04 members via livestream from 8.35 pm...

Villa Fiorito, River Plate, Ligue 1, the World Cup final and now Bayer 04: Facundo Medina’s life story so far has been shaped by special places, clubs, matches and names. One of them is Diego Maradona, who, like Medina, hailed from the south of Buenos Aires. Another is Exequiel Palacios, his former team-mate at River Plate, who was raving about Bayer 04 to him as recently as the World Cup in North America. Medina has now taken the plunge into the Bundesliga and, as an Argentine World Cup runner-up, has joined Bayer 04 from Olympique de Marseille this week. It is set to be the next successful chapter in his career. Leverkusen’s new number 2 brings with him a South American mentality and passion, a wealth of experience from many years in Ligue 1, and a fascinating story to the Rhineland – and to a club where the 1.84-metre-tall left-footed player will be reunited with Palacios and several other familiar faces.
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Welcome back! On Tuesday morning, 11 August, Jarell Quansah and Exequiel Palacios – the last of the Werkself’s World Cup participants – returned to training. The two medallists and their team-mates are set to play their final two pre-season friendlies in England this week before the start of competitive fixtures.
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