
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

A special afternoon at the Bayer 04 Football Academy autumn camp: At the Liga 20 indoor football centre, in the shadow of the BayArena, two Werkself women’s team players led a training session. Loreen Bender and Selina Ostermeier not only offered the young players advice and support, but also got stuck in themselves.
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Werkself-TV shows the highlights of Bayer 04's 5-2 win against 1. FC Nürnberg in the second round of the DFB-Pokal 2026/27...
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Bayer 04 came from 2-0 down to beat Nürnberg 5-2 in the second round of the 2026/27 DFB Pokal on Wednesday night. Edmond Tapsoba’s double either side of half-time sparked the turnaround, before Patrik Schick, Jonas Hofmann and Lucas Vázquez ensured progress to the last 16 for the 2024 cup winners.
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The Werkself have reached at least the semi-finals of the DFB Pokal in each of the last three years. The Black-and-Reds would like to make it to the final four of the competition again this season, but to do that they'll need to overcome 1. FC Nürnberg in round two, who travel to the BayArena with momentum following a successful league campaign so far. However, Bayer have a 100 percent record at home in all competitions this season - and have also won six of their last seven home matches in the Pokal. The Matchday News.
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