The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
A simple approach to sport with games, fun and a highlight at the end: Bayer 04 organised a very special training session for 40 participants aged between six and 27 in cooperation with the Football Association of the Middle Rhine (FVM). At the day of action for women and girls with disabilities at the Kurtekotten Performance Centre, many of the participants gained their first experience of football.
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On Saturday, 28 March, the lights will go out again at the BayArena from 20:30 pm to 21:30. As in previous years, Bayer 04 once again take part in the WWF Earth Hour campaign under the motto "We're switching off" as the club wants to set a collective example for more climate and environmental protection together with people, cities and companies around the world.
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Bayer 04 Leverkusen are bringing back Kerim Alajbegovic, who joined Red Bull Salzburg in the summer of 2025. The Bundesliga club activated the buy-back option in the contract with the Bosnia international, who has enjoyed great success at the Austrian top-flight club since the start of the current season. Alajbegovic moved to Salzburg from the Leverkusen U19s last year. The 1.86-metre forward has signed a five-year contract at Leverkusen with a start date of 1 July 2026.
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Less than a year ago, Kerim Alajbegovic moved from the Bayer 04 U19s to Austrian top-flight club FC Red Bull Salzburg. The forward’s development since then has been impressive. In 36 matches, including in the UEFA Europa League, the 18-year-old has scored 14 goals. In the summer, Alajbegovic, now a Bosnia international, will return to Leverkusen - and thus not only achieve the next milestone still early in his career, but also enrich the Werkself squad with his footballing versatility and determination.
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Bayer 04 Leverkusen have extended the contract with forward Nathan Tella ahead of schedule. The versatile 26-year-old, who can be deployed as a right winger, false nine or left winger, has penned a new contract to 30 June 2031. Tella joined the Werkself from Championship club Southampton in 2023. His previous contract ran to the summer of 2028.
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