
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

From special edition jerseys to fan banners, the home game against Mainz 05 was all about the many Bayer 04 fan clubs. Accordingly, a fitting tribute to the long-standing Werkself supporters was not to be missed during half-time in the Bundesliga match. Fernando Carro, CEO, honoured the up to 50-year anniversaries of six fan clubs in front of the coaches' benches at the BayArena.
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There’s lots going on at the BayArena today. The home game against FSV Mainz 05 is all about the numerous Bayer 04 fan clubs, whose birth - the founding of the "1. Fanclub 1976 Leverkusen" - dates back 50 years. A number of fan club representatives will be involved in awards, a banner display and a half-time matchday chat, and the Werkself are set to play in a special white fan club jersey. During half-time, Leverkusen mayor Stefan Hebbel and javelin world champion Steffi Nerius will also talk about the Olympic bid involving Leverkusen. Black and Red fans are advised to get to the stadium in good time today. Matchday news.
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The Werkself host Premier League club Arsenal in the Round of 16 first leg in the 2025/26 UEFA Champions League campaign. The match at the BayArena is on 10/11 March. Read on for information on ticket sales for this fixture.
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The draw for the Round of 16 in the UEFA Champions League 2025/26 was made today, Friday 27 February: Bayer 04 face Premier League leaders Arsenal. Managing director sport Simon Rolfes sees the English team as a "top opponent" and is looking forward to meeting former Werkself players Kai Havertz and Piero Hincapie again.
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After three consecutive victories, FSV Mainz 05 recently suffered setbacks against Borussia Dortmund (0-4) and Hamburger SV (1-1) in the battle to stay up. Nevertheless, the Mainz 05 performance curve has shown a clear upward trend in recent weeks. Their coach and a former Leverkusen player in particular have played a decisive role in this. The lowdown on our next opponents.
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