
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Werkself-TV shows the highlights of the Bayer 04 women's 0-1 loss against TSG Hoffenheim on the 19th matchday of the Google Pixel Frauen-Bundesliga 2025/26.
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The Bayer 04 Women suffered a setback in the race for third place in the Bundesliga table. Coach Roberto Pätzold's team lost 1-0 at home to direct rivals TSG Hoffenheim on Sunday afternoon, with a penalty after two minutes deciding the match. With 32 points and a game in hand, TSG have moved above the Werkself, who remain on 31 points. There is now a three-week international break before the remaining seven Bundesliga matches.
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Bayer 04 Leverkusen will have to manage without defender Loïc Badé for the time being. The Frenchman suffered a muscle injury in his right thigh in Saturday’s 1-0 Bundesliga defeat at FC Union Berlin. The diagnosis was the result of an MRI scan this Sunday morning.
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It is an expression of solidarity and a tribute to the unique fan culture Under the Cross: Bayer 04 Leverkusen make a special statement with the "50 Years of Fan Clubs" jersey. To mark the founding of the "First Fan Club 1976 Leverkusen", which was followed by many more over the years right up to the present day, the Bundesliga club is commemorating 50 years of passion with this new jersey. Highs and lows, successes celebrated together as well as defeats suffered are manifested in this piece of white fabric, a symbol of unwavering identification with the Werkself.
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