
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Under Carles Martínez, the Werkself have so far proved unbeatable at the BayArena. The Spaniard has led his team to victory in all three of their most recent home matches – and, it's worth noting, without conceding a single goal. On Sunday, 18 October (kick-off: 15:30 CEST / live on DAZN and Werkself Radio), current league leaders SC Freiburg will make the trip to Leverkusen, but will be without their top scorer. What's more, the Werkself have won all three of their previous home matches against the Black Forest club. With a goal, Patrik Schick could not only secure a fourth consecutive victory but also set a memorable record. Meanwhile, on what will be the ‘Health Day' at the BayArena, much of the focus will be on physical wellbeing. Today's matchday news.
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Bayer 04 Women missed out on victory in the Google Pixel Bundesliga as they were held to a draw at home to Eintracht Frankfurt on Saturday. Estrella Merino Gonzalez had put the Werkself ahead directly from a corner at the Ulrich-Haberland-Stadion, before Laura Freigang levelled for the visitors as it finished all square between fourth and third on Matchday 7.
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Freiburg have made an impressive start to the season, unbeaten in nine games across all competitions, with eight of them wins. Now the Bundesliga leaders come to the BayArena on Sunday to take on the Werkself, but Julian Schuster’s team will be missing their top scorer. Here’s the lowdown on our next opponent.
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Bayer 04 will have to manage without attacking midfielder Martin Terrier for the time being. The Frenchman sustained a muscle injury to his left hamstring yesterday, Thursday 15 October, during the Europa League game against Polish champions Lech Poznan (4–0). Terrier is not expected to be available until late December.
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