The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Bayer 04 Leverkusen have appointed Carles Martínez Novell as the new head coach. The 42-year-old Spaniard worked for FC Toulouse in the French Ligue 1 until the end of the season. Martínez finished last term in ninth place with the club from the south of France. He will take over the Werkself on 1 July 2026 and has signed a contract to 30 June 2028. Martínez, whose contract with Toulouse expires at the end of the month, succeeds Kasper Hjulmand at Leverkusen, who is leaving the club after one season.
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Welcome to Leverkusen, Carles Martínez Novell. Bayer 04 have appointed the 42-year-old Spaniard as the new head coach on a contract to 2028. Martínez most recently worked for FC Toulouse in the French Ligue 1 until the end of the season. He previously spent four years at Barcelona's legendary academy La Masia in his home city. Bayer04.de introduces Martínez in more detail.
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Bayer 04 plans for the 2026/27 pre-season continue to take shape. The Werkself will kick off the new season in mid-July with the return to the training ground. The highlight will be the official season opener on 8 August at the BayArena, including a friendly against La Liga club Sevilla. Friendlies in Germany will take the team to neighbouring Monheim, Offenbach and Jena.
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Strengthening the Bayer 04 Leverkusen youth teams: Konstantinos Kotsifakis will join the Werkself from Bundesliga 2 club Hertha Berlin for the 2026/27 season, where he will be a permanent member of the Leverkusen U19 coaching set-up. The German-Greek will also take on an operational role in coaching the Bayer 04 Future Team. The 29-year-old was most recently head coach of the U17s at Hertha Berlin.
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Another award for the Bayer 04 head groundsman and staff: After coming top in the 2021/22, 2022/23 and 2024/25 seasons, the BayArena pitch came second in the Bundesliga Pitch of the Year ranking for the 2025/26 season. VfL Wolfsburg secured the top spot this year, with TSG Hoffenheim in third place.
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