
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Fans at the BayArena got to enjoy a spectacle on Wednesday as the Werkself came from behind to beat Nürnberg 5-2 in the DFB Pokal. Now with the sixth home game of the season, can Bayer 04 maintain their perfect record in Leverkusen as VfB Stuttgart come to town in the Bundesliga on Saturday (15:30 CET)? The visitors have had issues domestically this term, sitting in 15th place, although they have had much better results in the UEFA Champions League. Here’s all you need to know ahead of the Matchday 8 encounter…
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Three days after the spectacular comeback in the DFB Pokal tie against FC Nürnberg (5–2), the Werkself face their next challenge in the Bundesliga. On Saturday, 31 October (kick-off: 15:30 CET), Bayer 04 host VfB Stuttgart, currently 15th in the table, at the BayArena. Ahead of the match, Carles Martínez spoke, amongst other things, about important factors in preparing for this next game given a tight fixture list.
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Despite VfB Stuttgart performing well in the Champions League, they are facing a difficult spell early on in the Bundesliga. Three days after their last-minute victory in the DFB Pokal at SC Paderborn 07, the Swabians can now take to the pitch at the BayArena with greater confidence on Saturday, 31 October (kick-off: 15:30 CET). The lowdown on our next opponents.
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A special afternoon at the Bayer 04 Football Academy autumn camp: At the Liga 20 indoor football centre, in the shadow of the BayArena, two Werkself women’s team players led a training session. Loreen Bender and Selina Ostermeier not only offered the young players advice and support, but also got stuck in themselves.
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