
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Freiburg’s defeat to Eintracht Frankfurt last weekend left them two places but a whole 10 points behind Bayer 04. Their results in general may be mixed, but Julian Schuster’s side are a force to be reckoned with at home, where they have earned 24 of their 33 points. Leverkusen may choose to look for the aerial route if they’re to get the better of their hosts, who have conceded more headed goals than any other team. Here’s all you need to know ahead of Saturday afternoon’s game in our matchday news.
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A boost for the second Bundesliga away game in a row: The Werkself take on SC Freiburg just three days after the convincing 1-0 win at Hamburger SV. Ahead of the game on Saturday, 7 March (kick-off: 15:30 CET), head coach Kasper Hjulmand spoke about the lessons learned from the rearranged fixture at HSV, a trio on yellow cards and young players like Christian Kofane and Montrell Culbreath.
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SC Freiburg suffered their eighth away defeat of the season in Frankfurt last weekend. But at home, at the Europa Park Stadion, coach Julian Schuster's team are clocking up one win after the next. SCF are unbeaten in the last 16 matches at home. On Saturday, 7 March (kick-off: 15:30 CET), they will be looking to keep the run going in the clash with the Werkself. The lowdown on our next opponents.
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For the third time in a row, the Leverkusen eSports players have made it through to the final round of the VBL Club Championship. From 7 to 8 March, they will compete for the German Club Championship at XPERION in Hamburg. At the start of the final round, they face Hamburger SV in the Round of 16. The match starts at 19:30 CET on Saturday, 7 March and will be broadcast live on the VBL Twitch channel. The eSports preview.
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