The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Bayer 04 will have to manage without attacking midfielder Martin Terrier for the time being. The Frenchman sustained a muscle injury to his left hamstring yesterday, Thursday 15 October, during the Europa League game against Polish champions Lech Poznan (4–0). Terrier is not expected to be available until late December.
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Following the international break, the Bayer 04 women’s team face their next head-to-head clash in the race for a top spot in the Bundesliga. In Saturday’s home match (14:00 CEST), the fourth-placed side host third-placed Eintracht Frankfurt at the Ulrich Haberland Stadium. Head coach Roberto Pätzold is well aware of the great opportunity this presents for his team.
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Malik Tillman described Leverkusen’s first European competition game in Poland in more than three decades as a “successful trip”. On matchday 2 in the group stage of the 2026/27 UEFA Europa League, the Werkself secured a commanding 4–0 victory away at champions Lech Poznan, a result that brought a number of positives. This fourth win in a row should also provide further momentum for the upcoming home fixture. The Werkself review of the Europa League night in Poland.
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Werkself TV shows the highlights of Bayer 04's 4-0 win at Lech Poznan on Matchday 2 of the 2026/27 Europa League season...
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