
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Werkself-TV shows the highlights of the Bayer 04 women's 4-0 win at SGS Essen on the 24th matchday of the Google Pixel Frauen-Bundesliga 2025/26.
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In the previous game against RB Leipzig in December last year, the Werkself turned came from behind to win 3-1 and further improved Leverkusen's already strong record against the Red Bulls. Montrell Culbreath stood out with his first goal on his debut for the Black and Reds. While the 18-year-old would certainly like to score a second goal against Leipzig on Saturday night, the attack-minded visitors come to the BayArena in confident mood after five Bundesliga victories in a row. The Nordkurve12 supporters group knows the Werkself will therefore once again be reliant on the vociferous support of the fans, and has once again called for the ‘Finally Red’ campaign in the run-in. Today’s matchday news.
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Video games manufacturer Electronic Arts (EA), together with the German Football League (DFL), announced the top male and female selections for the 2025/26 Bundesliga season this week. Bayer 04 striker Vanessa Fudalla is in the starting eleven of the women's "Team of the Season". Alejandro Grimaldo and Aleix Garcia have been selected as bench players in the men's team.
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After matchday 31 and the 2-1 derby win in Cologne, one thing is certain: Bayer 04 will at least compete in the UEFA Europa League in the coming 2026/27 campaign. But the Werkself want more. Looking at the race for Champions League qualification and the remaining three league fixtures, including against direct rivals, bayer04.de outlines the possible scenarios in the season run-in.
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This special event showed once again how strong Bayer 04 are as a team: As part of ‘BarmeniaGothaer gives joy’, the Werkself players Edmond Tapsoba, Ibrahim Maza and Christian Kofane supported the sale of individually designed T-shirts for a good cause at the Fanwelt on Thursday. Several hundred fans came to take part in the charity campaign. Leverkusen's main sponsor BarmeniaGothaer donated the proceeds to the Fondation Edmond Tapsoba, which helps people in Tapsoba's home country of Burkina Faso in their challenging everyday lives.
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