
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

With the European season ticket, fans can follow and support the Werkself on the European stage during the 2026/27 season – and are guaranteed a ticket and a seat for every UEL home match at the BayArena, right up to and including a potential semi-final. In addition, holders of the European season ticket save 20 per cent on each UEL ticket.
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Bayer 04 Women warmed up for the start of the Bundesliga season with an emphatic 7-0 victory over Belgian top-flight club Standard Liège on Saturday afternoon. Over four periods of 30 minutes, Cornelia Kramer, Lilla Turanyi and Valentina Mädl each netted a brace for the dominant Werkself, after Loreen Bender had opened the scoring. Roberto Pätzold's side kick off their league campaign at RB Leipzig in eight days.
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After the 2-1 defeat at Premier League club Nottingham Forest the night before, it was straight back to work for the Werkself at midday on Thursday with an intensive training session in hot temperatures at the hosts' training ground.
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Werkself TV shows the highlights of the 1-2 loss in the friendly match at Nottingham Forest...
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The Werkself suffered a first defeat in the current pre-season fixtures. The sixth friendly of the summer ended in 2-1 reverse at Premier League Nottingham Forest. The English side took an early lead (4’) but Patrik Schick levelled just after the half-hour mark (32’). Nothing much happened after that, and the match looked set to end in a draw. However, the hosts managed to score the winning goal late on (90').
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