
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

This special event showed once again how strong Bayer 04 are as a team: As part of ‘BarmeniaGothaer gives joy’, the Werkself players Edmond Tapsoba, Ibrahim Maza and Christian Kofane supported the sale of individually designed T-shirts for a good cause at the Fanwelt on Thursday. Several hundred fans came to take part in the charity campaign. Leverkusen's main sponsor BarmeniaGothaer donated the proceeds to the Fondation Edmond Tapsoba, which helps people in Tapsoba's home country of Burkina Faso in their challenging everyday lives.
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With three games to play before the end of the season, the Bayer 04 Women can break one record and equal another at SGS Essen. After three wins on the bounce, coach Roberto Pätzold's team are aiming to maintain the chance of third place in Sunday’s away game (14:00 CEST, Stadion an der Hafenstraße).
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Rüdiger Vollborn has been at the club for 40 years, he holds the record number of Bundesliga appearances for the club (401) and is the only Bayer 04 player to have won both the UEFA Cup (1988) and the DFB Pokal (1993). And the Berliner stayed with the Werkself after ending his impressive playing career as he worked as a goalkeeping coach for the following nine years. Vollborn now works under the Bayer Cross as a fan liaison officer and club archivist. Since February 2021, the personalised Black and Red lexicon takes Werkself fans under the heading of 'Rudi recounts...' on a brief trip through the history of Bayer 04 every month…
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From Ouagadougou to Leverkusen – and back: in March, Bayer 04 travelled with Edmond Tapsoba for a special project in his homeland Burkina Faso. The country where his roots and heart lie. The country where he’s more than a world-class defender: a symbol of hope and a role model for an entire generation. The result is a 45-minute documentary about Tapsoba’s long journey from Africa via Portugal to Leverkusen, which offers extraordinary, one-off and emotional insights.
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Edmond Tapsoba has signed an early extension to his contract with Bayer 04 Leverkusen. With two years left on his current deal, the 27-year-old Burkina Faso international has extended his contract until 30 June 2031. The centre-back joined as a young talent from Portuguese top-flight club Vitoria Guimaraes at the start of 2020.
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