
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Edmond Tapsoba has signed an early extension to his contract with Bayer 04 Leverkusen. With two years left on his current deal, the 27-year-old Burkina Faso international has extended his contract until 30 June 2031. The centre-back joined as a young talent from Portuguese top-flight club Vitoria Guimaraes at the start of 2020.
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A special surprise: during the preview for the 'Fierté Burkinabè' documentary about Edmond Tapsoba, Bayer 04 directors Fernando Carro and Simon Rolfes announced Tapsoba's contract extension until 2031 together with the centre-back. He then spoke to Werkself-TV about his time in Leverkusen so far and future ambitions...
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This evening was deeply moving: At a really special setting, Bayer 04 exclusively presented the specially produced documentary ‘Fierté Burkinabè’ ("Burkinabe Pride") about Edmond Tapsoba on Tuesday. For the preview at the BayArena, the parents of the Werkself player and other close companions travelled all the way from his African homeland Burkina Faso. The 45-minute film shows Tapsoba's extraordinary career from his beginnings in Ouagadougou to Leverkusen as well as the work of his foundation "Fondation Edmond Tapsoba", with representatives from Burkina Faso also present. Fans can watch the documentary free of charge on Werkself TV and YouTube from Wednesday night at 20:00 CEST.
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Bayer 04 have signed left-back Carolin Simon from champions Bayern Munich for the coming season. The 33-year-old former Germany international, who played for Leverkusen from 2013 to 2016, has signed a contract to 30 June 2028.
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Bayer 04 Women have strengthened for the coming season with the signing of Lobke Loone. The 23-year-old Dutch striker joins from Utrecht on a contract until 30 June 2028.
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