
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The European jersey has been launched, the UEL opponents have been drawn – and anticipation for the European campaign is running high. To mark the occasion, an autograph session was held on Friday afternoon, 28 August, at the Fanwelt with current Werkself player Montrell Culbreath and official club legend Paulo Sergio.
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After six and a half years, Exequiel Palacios is leaving the Bundesliga and moving from Bayer 04 to the Premier League. The Argentine, who as a Werkself player won the World Cup with his national team four years ago and finished as runners-up at this summer’s tournament, will play for newly promoted English side Ipswich Town with immediate effect. The 27-year-old, whose contract in Leverkusen was due to run until 30 June 2030, joined Bayer 04 in January 2020 as a promising young talent. He steadily developed into one of the best defensive midfielders in the German top flight.
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When Exequiel Palacios moved from the Argentinian club River Plate to Bayer Leverkusen on 1 January 2020, the then 21-year-old could not have imagined just how successful the next six and a half years would be for him. Pala, as he is known, had already won the Copa Libertadores – the most prestigious competition in South American club football – with River Plate. But there were still so many more trophies to come.
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To mark Exequiel Palacios’s departure, we’ve put together a compilation of the midfielder’s finest and most important goals from his six-and-a-half years at the club.
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