
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The United Nations International Day of Persons with Disabilities (IDPD) is celebrated worldwide on 3 December. Together with Bayer AG, Bayer 04 is once again setting an example for diversity and inclusion by lighting up the BayArena in purple in the evening.
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For the second time in four days, Bayer 04 face Borussia Dortmund this Tuesday evening, 2 December (kick-off: 21:00 CET) - this time in the round of 16 of the DFB Pokal, with more than 7,000 fans supporting the Werkself at Signal Iduna Park. After the recent 2-1 defeat to BVB in the league, several cup stats provide hope of revenge for the Black and Reds. There are several reasons why Bayer 04 recommends getting to the round of 16 clash early, in which VAR will be in use, unlike in the previous rounds. Read on for further information on tonight’s game in our matchday news.
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Just three days on from the Bundesliga meeting in Leverkusen, Bayer 04 now visit Borussia Dortmund in the DFB Pokal on Tuesday (21:00 CET). Ahead of the game at the Signal Iduna Park, head coach Kasper Hjulmand spoke about how to approach this second encounter in 72 hours and a number of developments within the squad.
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Werkself TV shows the highlights of Bayer 04's 2-1 loss to Borussia Dortmund on Matchday 12 of the 2025/26 Bundesliga season...