The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Strengthening the Bayer 04 Leverkusen youth teams: Konstantinos Kotsifakis will join the Werkself from Bundesliga 2 club Hertha Berlin for the 2026/27 season, where he will be a permanent member of the Leverkusen U19 coaching set-up. The German-Greek will also take on an operational role in coaching the Bayer 04 Future Team. The 29-year-old was most recently head coach of the U17s at Hertha Berlin.
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Another award for the Bayer 04 head groundsman and staff: After coming top in the 2021/22, 2022/23 and 2024/25 seasons, the BayArena pitch came second in the Bundesliga Pitch of the Year ranking for the 2025/26 season. VfL Wolfsburg secured the top spot this year, with TSG Hoffenheim in third place.
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Opening opponents, derby weekends, the opponents in the season finale: This information and more will be available to Bayer 04 fans on Thursday, 2 July, when the 2026/27 Bundesliga fixture list is published.
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The next footballing highlight is just around the corner: the 2026 FIFA World Cup, the 23rd edition of the tournament, will be held in the USA, Canada and Mexico and feature 48 teams for the first time. Bayer04.de has all the latest on the Werkself players called up to represent their countries.
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While the majority of the Bayer 04 Women are enjoying their summer break, nine Werkself players will be on duty for their national teams in the coming days. Three of them are competing for a place at the World Cup, while six are involved in two friendlies with the Germany U23 team.
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