
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Rüdiger Vollborn has been at the club for 40 years, he holds the record number of Bundesliga appearances for the club (401) and is the only Bayer 04 player to have won both the UEFA Cup (1988) and the DFB Pokal (1993). And the Berliner stayed with the Werkself after ending his impressive playing career as he worked as a goalkeeping coach for the following nine years. Vollborn now works under the Bayer Cross as a fan liaison officer and club archivist. Since February 2021, the personalised Black and Red lexicon takes Werkself fans under the heading of 'Rudi recounts...' on a brief trip through the history of Bayer 04 every month.
Show more
Kasper Hjulmand has led the Werkself back to winning ways and is back in the knockout phase of the UEFA Champions League with Bayer 04 after the 3-0 win against Villarreal on Wednesday evening. In an interview with the Werkself magazine at the BayArena in the team meeting room, directly opposite the dressing room, he provided some special insights for the current issue, which was published in January. A conversation with the 53-year-old coach about values, attitudes and personal experiences as well as interests outside of football.
Show more
The thrilling 3-1 win for Bayer 04 against Eintracht Frankfurt in the Hinrunde is a fond memory for Alejandro Grimaldo, with his brace from free kicks, and coach Kasper Hjulmand, who was in the dugout under the Cross for the first time. Now comes the return fixture in the metropolis on the River Main and after going out of the DFB Pokal and the Champions League, the full focus at Eintracht, currently managed by two interim coaches, is now on the Bundesliga. For their part, the Werkself will do everything in their power to continue the longest winning run against a Bundesliga club. The matchday news.
Show more
Bayer 04 have ended Artem Stepanov’s loan deal at Nürnberg and agreed a new loan to Utrecht in the Netherlands. The Ukrainian striker did not play as much as hoped for at the Bundesliga 2 club and will now continue his development in the Eredivisie for the rest of 2025/26.
Show more
The draw for the knockout play-offs of the 2025/26 UEFA Champions League was made on Friday, 30 January and saw Bayer 04 paired with Olympiacos. It’s a reunion with the Greek side following the Werkself’s 2-0 loss in Athens on Matchday 7 of the league phase.
Show more