The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Full-back Julia Mickenhagen is leaving Bayer 04 Leverkusen at the end of the season to join Bundesliga newcomers VfB Stuttgart. The 21-year-old’s contract with the club expires on 30 June.
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Werkself-TV shows the highlights of the Bayer 04 women's 3-1 win at RB Leipzig on the 25th matchday of the Google Pixel Frauen-Bundesliga 2025/26.
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In the next head-to-head clash for the Champions League places at VfB Stuttgart, Bayer 04 failed to follow up their impressive 4-1 win at home to RB Leipzig from the week before. After Aleix Garcia gave the Werkself the lead with their fastest goal of the season, the Swabians turned the game around and won 3-1, knocking Leverkusen down into sixth place. It leaves them needing a win at home to Hamburger SV and other results to go their way on the final day of the 2025/26 campaign in order to reclaim fourth spot. The Werkself Review has all the analysis and reaction from all those involved in an eventful encounter with VfB.
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