
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Bayer 04 can go through to the Round of 16 of the UEFA Champions League for the ninth time tonight, 24 February (kick-off: 21:00 CET) and be in the top 16 clubs in Europe. A good omen: Leverkusen have progressed to the next round after winning the first leg in 20 of their 22 knockout rounds in European competitions to date. For their part, Greek record champions Olympiacos rested several players for last weekend’s league fixture ahead of the play-off second leg at the BayArena and will now do everything in their power to turn the tide with their usual aggressive and high pressing. The discussions on Werkself radio are likely to be just as intense as the battle on the pitch, with commentator Florian Bechholz welcoming honorary captain Stefan Kießling and goalkeeper Mark Flekken. Today’s matchday news.
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With the advantage of the 2-0 first-leg win in the play-offs, the Werkself are looking to book their place in the last 16 of the UEFA Champions League at the sold-out BayArena. Ahead of the home game against Olympiacos on Tuesday, 24 February (kick-off: 21:00 CET), coach Kasper Hjulmand and goalkeeper Janis Blaswich spoke about the position ahead of the match, the visitors' strength at set-pieces and a personnel issue for the home side.
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With a win in the Greek Super League last weekend, Olympiacos achieved success on the pitch ahead of the UEFA Champions League play-off second leg at Bayer 04 on Tuesday, 24 February (kick-off: 21:00 CET). Coach José Luis Mendilibar rested many of his regular starters.
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Werkself-TV shows the highlights of the Bayer 04 women's 0-1 loss against TSG Hoffenheim on the 19th matchday of the Google Pixel Frauen-Bundesliga 2025/26.
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