The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Bayer 04 Leverkusen have signed France U17 international Kenan Doganay. The 1.90-metre-tall defensive midfielder, who has Turkish roots, joins Leverkusen from the U19s at French top-flight club Olympique Lyon. He will initially train with and play for the U19 team.
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The Sports Tribunal of the German Football Association (DFB) has fined Bayer 04 Leverkusen €185,000 for spectators setting off pyrotechnic devices during a total of five competitive matches. This relates to four Bundesliga matches and the DFB Pokal semi-final against Bayern Munich. The highest individual fine relates to the away match at FC Köln at the end of April.
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Bayer 04 Leverkusen have extended the contract with U19 goalkeeper Simeon Rapsch. The Germany youth international goalkeeper has signed a long-term contract with the Werkself running to 30 June 2029. The 18-year-old joined Leverkusen from FC Viktoria Köln in the summer of 2024.
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Ken Izekor is leaving Bayer 04 Leverkusen to join third-tier side Alemannia Aachen with immediate effect. The 19-year-old centre-forward joined the club from Alemannia in 2018, and Izekor is now returning to his hometown.
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