
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The Werkself need a win in their penultimate match of the season at RB Leipzig on Monday evening (18:00 CEST) to keep their hopes of third place alive until the final day. After Eintracht Frankfurt lost on Saturday, Roberto Pätzold's side can close the gap on their rivals to two points and leave it all to play for next Sunday.
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Werkself TV shows the highlights of Bayer 04's 1-3 loss at VfB Stuttgart on Matchday 33 of the 2025/26 Bundesliga season...
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Down to fifth from fourth place despite taking an early lead: in the head-to-head for a Champions League spot, Bayer 04 were 1-0 up at VfB Stuttgart with just a minute played thanks to an Aleix Garcia strike, but ultimately lost 3-1 (2-1) to the more determined hosts. It meant the Swabians leapfrogged the Werkself in the Bundesliga table on the penultimate matchday.
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Today sees Bayer 04 go head-to-head with their next direct rivals in the race for Champions League qualification (kick-off 15:30 CEST). Opponents Stuttgart are currently fifth in the table, level on points with the Werkself but one place below them due to a three-goal inferior goal difference. The Black and Reds' record at Bad Cannstatt tells a clearer story: they've not lost at VfB for over 16 years. One important factor in securing what would be three crucial points away from home is Leverkusen's strength on the counter-attack. Whilst Stuttgart are also extremely dangerous going forward, they will be without their captain. Today’s matchday news.
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