
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The German Football League (DFL) has announced the three candidates for the title of Bundesliga Rookie of the Month for January. That includes Werkself player Jarell Quansah. Fans of Bayer 04 can vote for their favourite on the Bundesliga app from now until Thursday, 5 January (23:59 CET).
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As in the past two years, the Werkself are aiming to come out on top in the DFB Pokal quarter-finals on Tuesday night, 3 February (kick-off: 20:45 CET). With eleven home games in a row without defeat against the Kiezkicker, the Black and Reds go into the floodlit match in confident mood. But the Pokal, as is often said, has its own magic and the team from the Millerntor has much more to offer than the current 17th place in the Bundesliga would suggest. After all, Bayer 04 are one of the big German teams the combative Hamburgers have already made life difficult for this season. The matchday news.
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The Leverkusen eSports team picked up valuable points and made up ground in the overall table with a top four finish in the offline round in Showdown 4 in the VBL Club Championship 2025/26. In the round of 16, Showdown 1 winners Bayer 04 defeated the unbeaten runners-up in the previous round, VfL Bochum, in a thrilling penalty shoot-out. The Landwehr cousins, themselves the current club runners-up, then beat the current club champions and Showdown 3 winners RB Leipzig. It was not until the semi-finals that they lost out to the eventual showdown winners Borussia Mönchengladbach.
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Bayer 04 Leverkusen have strengthened the goalkeeper position for the second half of the season. Germany keeper Rafaela Borggräfe has joined the Werkself on loan from English FA Women's Super League (WSL) club Liverpool until the end of the season.
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Bayer 04 have agreed a loan move for U19s striker Ken Izekor to join Bundesliga 2 club Eintracht Braunschweig on loan for the rest of the 2025/26 season.
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