
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Bayer 04 are riding a wave of success on the European stage: After three wins from their first three games and as the only team yet to concede a goal, the Werkself sit second in the table in the group stage of the UEFA Europa League. With another three points in their first-ever competitive match against Olympique Marseille on Thursday night, 5 November (kick-off: 21:00 CET), Bayer 04 could leap to the top of the table. Meanwhile, the French side are riding the wave of a winning streak in Ligue 1, but are yet to pick up any points in the Europa League. For one Werkself player, Thursday night will mark a reunion with his former team-mates. Today’s matchday news.
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The Europa League campaign continues: Bayer 04 host Olympique Marseille at the BayArena on matchday four of the group stage on Thursday 5 November (kick-off: 21:00 CET). Ahead of the clash against the club from the French Mediterranean coast, head coach Carles Martínez spoke about the visitors’ form and had some good news regarding the squad. Former OM player Facundo Medina spoke, amongst other things, about the factors that will be crucial against his old club.
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The Bayer 04 Round of 16 tie in the 2026/27 DFB Pokal has been scheduled. The Werkself will host Bundesliga rivals RB Leipzig on Wednesday, 2 December, at 18:00 CET. That was announced by the German Football Association (DFB).
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Video game developer Electronic Arts (EA), in collaboration with the Bundesliga, has announced the six nominees for the Bundesliga Player of the Month award for October 2026 – and Bayer 04’s Ibrahim Maza is among them. Fans of the Black and Reds can vote from now until Sunday 8 November (23:59 CET).
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