
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

At the end of the winter training camp in Portugal, the Bayer 04 Women convincingly mastered their friendly ahead of the start of the second half of the season. In the match against Swiss league leaders Servette FCCF, coach Roberto Pätzold's team won 3-0 at the Monte Gordo Sports Complex. Carlotta Wamser (4’), Vanessa Fudalla (18’) and Loreen Bender (53’) scored for Bayer 04, who have been preparing for the Rückrunde in the Algarve since last Saturday.
Show more
In the first episode of the new interview series "A New Chapter", Werkself defender Jarell Quansah reflects on his first few months under the Cross and speaks about his journey from England to Leverkusen. Having come through the ranks at Liverpool, a new chapter began for Quansah in the summer at Bayer 04 — with new objectives, fresh challenges and much ambition. In the video, the centre-back speaks about his development as a player and person, about the courage to leave your own comfort zone, and about what it means for him to be part of an international team in a different country. Honest, reflective and full of motivation — just like the start of his Werkself career.
Show more
Full focus on Hoffenheim: after the late postponement of the away match at Hamburger SV, the Werkself are looking forward. To get themselves in top shape for the key clash at top-six rivals TSG Hoffenheim on Saturday 17 January (kick-off 15:30 CET), a number of players showed full commitment even on a day off - including two AFCON returnees...
Show more
After Rio de Janeiro, it's off to Thuringia: This summer, Bayer 04 Leverkusen will prepare for the 2026/27 football season in Germany. While Brazil was the destination last year, the Werkself will now set up their training camp in Blankenhain, just outside Erfurt, from 1 to 7 August 2026.
Show more
Four Bayer 04 players are in action at the 35th edition of the Africa Cup of Nations being played in Morocco from 21 December to 18 January 2026: Eliesse Ben Seghir for the hosts, Edmond Tapsoba with Burkina Faso, Ibrahim Maza for Algeria and Christian Kofane with Cameroon. Updates on the AFCON matches involving Werkself players...
Show more