The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Midfielder Ruby Grant is leaving Bayer 04 Leverkusen and joining Portuguese runners-up Sporting CP a year before her contract expires. The 24-year-old has been at the Werkself since January 2025.
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Bayer 04 have loaned Brazilian full-back Arthur to Bundesliga side Werder Bremen for one year. Arthur Augusto de Matos Soares – the full name of the right-back – has a contract with Leverkusen until 30 June 2031. At Werder, the 23-year-old is expected to make an impact and help the long-established club further consolidate their position in the Bundesliga.
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Bayer 04 have loaned defender Jeanuel Belocian to Spanish top-flight side Racing Santander. The 21-year-old defender joins the team currently ninth in La Liga until the end of the current 2026/27 season. Belocian’s contract remains valid until 30 June 2029. Last season, the 1.86-metre-tall U21 international was loaned to VfL Wolfsburg for six months.
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He knows the dressing room, the pitch and the club. But, above all, he knows the feeling of playing for the Werkself at the BayArena: Moussa Diaby is back in Leverkusen after three years. The lightning-fast winger has signed a contract with Bayer 04 until 2031 and he will once again wear the number 19 jersey. The left-footed player previously played for the club from 2019 to 2023, having arrived in the Rhineland from his native France as a promising young talent and eventually leaving the club – having established himself as one of the Bundesliga’s best attackers – to join Aston Villa in the Premier League. Now he has returned to Bayer 04 from Al-Ittihad FC in Saudi Arabia.
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