
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Alejandro Grimaldo, of course! With his late equaliser (88') in the Champions League clash against Newcastle United, the Spaniard rescued a point for the Werkself, who took the lead through an own goal by Newcastle's Bruno Guimaraes (13') but went with two goals for the visitors scored by Anthony Gordon (51') and Lewis Miley (74'). It was the third draw for Bayer 04 in the current 2025/26 campaign on matchday 6 in the UCL league phase.
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The Werkself will be looking to continue their run in the Champions League against Newcastle United on Wednesday, 10 December (kick-off: 21:00 CET). The two victories without conceding a goal at Benfica (1:0) and Manchester City (2-0) will hopefully be followed by a win at home at the BayArena. Against the English side, who have a player with a Black and Red past in their ranks, the way to victory could be through efficiency in attack and quick transitional play. The latter in particular has recently caused the Magpies problems away from home on the European stage. Fans can also get the stylish matchday sticker for their Sound of Dreams tour pass at the Bayer 04 Fanwelt. The matchday news.
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For the first time ever, Bayer 04 have reached the knockout phase of the UEFA Youth League. At the end of the league phase, the Leverkusen U19s secured a 2-1 home win against Newcastle United on Wednesday, 10 December. Montrell Culbreath scored before half-time and Ferdinand Pohl doubled the lead after the restart in the clash with the English side. The UCL youth competition continues at the beginning of February with the Round of 32, which will be played away from home without a second leg.
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The Bayer 04 U19s today, Wednesday 10 December (kick-off: 14:00 CET), host Newcastle United on the sixth and final matchday in the league phase of the UEFA Youth League. For coach Kevin Brok's team, the game against the English side is about securing a place in the next stage of the competition and a historic first appearance in the knockout phase. Werkself TV will broadcast the match live and free of charge from the Ulrich Haberland Stadium from 13:50 CET...
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Will Bayer 04 emulate their away wins at Benfica and Manchester City? Newcastle United are the visitors at a sold-out BayArena on Wednesday, 10 December (kick-off: 21:00 CET/live on Werkself Radio) to round off the UEFA Champions League games for the year. Coach Kasper Hjulmand spoke in advance about the momentum in Europe's premier club competition and gave an encouraging personnel update. Jarell Quansah also spoke about his experiences playing against Nick Woltemade and his wish for the Bayer 04 fans.
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