The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Bayer 04 are back at the BayArena! Under the slogan “One day. Two teams. One club.”, the Leverkusen stadium grounds will be transformed into a world of experiences – with a wide range of exclusive activities both on and off the pitch. Keep track of all the highlights in our blog for the 2026 season launch.
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Kicking off the new season with a fresh look: Bayer 04, in collaboration with sportswear manufacturer New Balance, has unveiled the official kit for Leverkusen’s e-Sports players for the coming season. The jersey is now available from the Bayer 04 online shop and the Fanwelt.
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Paulo Sergio and Bayer 04 have enjoyed close ties since the Werkself training camp in his native Brazil last summer. The club legend is in charge of the Bayer 04 Soccer Academy, which opened in the summer of 2025, and he has also been at this year’s training camp in the Weimarer Land. As well as interacting with the many fans who travelled to the camp, the 1994 World Cup winner used the time to plan the next steps for the Academy together with club officials. In an interview with bayer04.de, Sergio spoke about the project’s future development, the upcoming visit by young Academy players to Leverkusen, and plans for the coming months in Germany and Brazil.
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A round-up of the Werkself training camp in the Weimarer Land, all in one place: in our daily blog you’ll find all the insights and updates from the day. Day five (Thursday 6 August) is as follows: The squad have the final open session of the training camp in the morning. After lunch, there will be a team event.
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When Afonso Moreira arrived for his interview with bayer04.de, he had to take a deep breath first. Asked how the morning session had gone, the 21-year-old replied with a slight smile: “Tough. Intense.” That’s really sums up the workload for the Werkself so far at the training camp in the Weimarer Land region. Head coach Carles Martínez and his team demand hard work, team spirit and the determination to improve every day. Those are values Moreira wholeheartedly identifies with – and the Portuguese player has not only taken them to heart, but also permanently noted in the form of a tattoo.
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