The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Bayer 04 will have to manage without defender Guéla Doué for the time being. The Ivory Coast international sustained a muscle injury to his right calf during the final Werkself training session yesterday ahead of the Europa League clash with Slovenian champions NK Celje.
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For the first time since reaching the final against AS Roma (2–2, first leg 2–0) in May 2024, Bayer 04 are playing another home match in the UEFA Europa League – and they will be wearing their new European kit. On Wednesday 16 September (kick-off: 21:00 CEST), the BayArena will welcome Slovenian champions NK Celje, who appointed a new coach this week following a mixed start to the season. Under the slogan “40 Years Across Europe. Still Creating History.”, the Black and Reds now aim to add the next chapter to their European history, which has seen so much success in recent years. Bayer 04 fans can follow the match on free-to-air TV on RTL, as well as on Sky and Werkself Radio. The matchday news.
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European football returns to the BayArena: Bayer 04 host Slovenian champions NK Celje on matchday 1 in the group stage of the 2026/27 UEFA Europa League. Ahead of the match on Wednesday 16 September (kick-off: 21:00 CEST), head coach Carles Martínez and midfielder Aleix Garcia spoke at the pre-match press conference. The focus was primarily on the great anticipation surrounding the competition and the clear objectives for it – and, given the circumstances, on a last-minute change to the opposition line-up.
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The champions of Slovenia NK Celje are in a European competition for the fourth time in their history. This Wednesday, 16 September (kick-off: 21:00 CEST), the side lead by head coach Vitor Campelos visit the BayArena for matchday 1 in the group stage in the UEFA Europa League. Celje’s last match at the weekend did not go to plan. The lowdown on our next opponents.
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Construction work continues on the ‘Haus der Talente’ on Kurtekottenweg in Leverkusen, where 36 young elite athletes will find a new home from next summer. The building team from Temmink Bau, led by Thomas Wellers, are hard at work. Over the past few days, excavators, wheeled loaders and rollers have removed 2,500 cubic metres of soil to excavate the basement.
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