The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Bayer 04 Leverkusen have appointed Carles Martínez Novell as the new head coach. The 42-year-old Spaniard worked for FC Toulouse in the French Ligue 1 until the end of the season. Martínez finished last term in ninth place with the club from the south of France. He will take over the Werkself on 1 July 2026 and has signed a contract to 30 June 2028. Martínez, whose contract with Toulouse expires at the end of the month, succeeds Kasper Hjulmand at Leverkusen, who is leaving the club after one season.
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Welcome to Leverkusen, Carles Martínez Novell. Bayer 04 have appointed the 42-year-old Spaniard as the new head coach on a contract to 2028. Martínez most recently worked for FC Toulouse in the French Ligue 1 until the end of the season. He previously spent four years at Barcelona's legendary academy La Masia in his home city. Bayer04.de introduces Martínez in more detail.
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Bayer 04 plans for the 2026/27 pre-season continue to take shape. The Werkself will kick off the new season in mid-July with the return to the training ground. The highlight will be the official season opener on 8 August at the BayArena, including a friendly against La Liga club Sevilla. Friendlies in Germany will take the team to neighbouring Monheim, Offenbach and Jena.
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Strengthening the Bayer 04 Leverkusen youth teams: Konstantinos Kotsifakis will join the Werkself from Bundesliga 2 club Hertha Berlin for the 2026/27 season, where he will be a permanent member of the Leverkusen U19 coaching set-up. The German-Greek will also take on an operational role in coaching the Bayer 04 Future Team. The 29-year-old was most recently head coach of the U17s at Hertha Berlin.
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Another award for the Bayer 04 head groundsman and staff: After coming top in the 2021/22, 2022/23 and 2024/25 seasons, the BayArena pitch came second in the Bundesliga Pitch of the Year ranking for the 2025/26 season. VfL Wolfsburg secured the top spot this year, with TSG Hoffenheim in third place.
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