The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Today sees Bayer 04 go head-to-head with their next direct rivals in the race for Champions League qualification (kick-off 15:30 CEST). Opponents Stuttgart are currently fifth in the table, level on points with the Werkself but one place below them due to a three-goal inferior goal difference. The Black and Reds' record at Bad Cannstatt tells a clearer story: they've not lost at VfB for over 16 years. One important factor in securing what would be three crucial points away from home is Leverkusen's strength on the counter-attack. Whilst Stuttgart are also extremely dangerous going forward, they will be without their captain. Today’s matchday news.
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Another showdown in the race for the Champions League places takes place in Swabia: on Saturday 9 May (kick-off 15:30 CEST), the Werkself visit VfB Stuttgart, who are only behind on goal difference. In his pre-match press conference, head coach Kasper Hjulmand spoke about confidence, excitement and mentality.
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Reinforcement in attack: Bayer 04 Leverkusen have secured the transfer of striker Maja Sternad from Bundesliga rivals SV Werder Bremen. The 22-year-old has signed a contract until 30 June 2028.
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It's a thrilling situation: as the season draws to a close, Stuttgart and Bayer 04 are heading into the home stretch almost neck and neck. After 32 games, with 17 wins, seven draws and eight defeats each, both teams are on 58 points. Even in terms of goals scored, VfB and the Werkself are level on 66. The Black and Reds have conceded just three fewer goals (43) than their rivals (46), which is why they sit one place behind fourth-placed Leverkusen. This Saturday, 9 May (kick-off: 15.30 CEST), the two teams go head to head at the MHP Arena in Stuttgart. The lowdown on our next opponents.
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