The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

The Werkself welcome FC Augsburg to the BayArena on Bundesliga matchday 30 in the 2025/26 season. The match on Saturday, 18 April kicks off at 15:30 CEST. Bayer 04 have organised a family matchday with exclusive offers for parents and children. Information on ticket sales.
Show more
The Werkself host VfL Wolfsburg at the BayArena on matchday 28 in the 2025/26 Bundesliga season. The match is on Saturday, 4 April, with the kick-off at 15:30 CET. Information on ticket sales.
Show more
The #B04 eSports team made a successful start to the 2025/26 VBL Club Championship finals. Marc and Sean Landwehr defeated the hosts of the event, Hamburger SV, in the Round of 16. The quarter-final in the German club championship will be played on Sunday, 8 March at 14:00 CET against SC Freiburg, who finished top of the table in the league phase.
Show more
Werkself TV shows the highlights of Bayer 04's 3-3 draw at SC Freiburg on Matchday 25 of the 2025/26 Bundesliga season...
Show more