The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Exciting experiences and exclusive insights into the Werkself and the BayArena awaited the young footballers from the BA04 Football Academy Guangzhou in China during their visit to the Rhineland this week. As well as taking part in a joint training session with the Bayer 04 Football Academy, the youngsters marvelled at the Bundesliga club’s stadium during a guided tour. The highlight of the visit was a private press conference with former Bayer 04 striker Stefan Kießling, during which he shared tips from his own career with the young players. On Saturday afternoon, 10 October, the group will round off their visit by supporting the Werkself in the away match in Mainz.
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During the first international break of the 2026/27 season, set to last just under three weeks, nine Bayer 04 first-team players are in action with their respective national teams. Read on for updates on matches featuring Werkself players…
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Fun, games and promising talent: At the fourth Bayer 04 Junior Girls’ Talent Day at the Kurtekotten training centre, 90 football-mad girls had the chance to put themselves forward for the Werkself youth teams. During a 90-minute training session, children born between 2011 and 2019 had the chance to demonstrate their skills.
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Austria or Kosovo? Claudia Wenger or Lumbardha Misini? Only one of these two Bayer 04 women will see her dream of competing at the World Cup in Brazil (24 June to 25 July 2027) live on beyond the next two weeks. From a Leverkusen perspective, the two direct clashes between the Werkself players as they battle for a place in the second play-off round stand out during the upcoming international break. For several other players, the chance of a World Cup place is also at stake. Bayer04.de provides an overview of the women’s international call-ups.
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