The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Bayer 04 have fond memories of their encounters with Heidenheim, including a resounding 6-0 win in the reverse fixture. Kasper Hjulmand’s side would very much like to produce a similarly clinical display as they now head to the Voith-Arena for Matchday 27 on Saturday (15:30 CET). But they come up against a team fighting for their Bundesliga lives at the bottom of the table, 10 points adrift of safety with time running out. Here’s all you need to know ahead of the game in our matchday news.
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The Bayer 04 Women welcome FC Carl Zeiss Jena to the Ulrich Haberland Stadium on Sunday night in a white retro look - and in a unique Bayer 04 ‘50 Years of Fan Clubs’ special edition jersey. In sporting terms, head coach Roberto Pätzold's team will face the Bundesliga's bottom team at 18:30 CET looking to keep their chances of third place in the table alive with six games left to play.
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Bayer 04 return to Bundesliga action this weekend. Following their elimination in the Round of 16 of the UEFA Champions League, the Werkself are away to FC Heidenheim 1846 on Saturday, 21 March (kick-off: 15:30 CET) on Bundesliga matchday 27. Ahead of the clash in the eastern Swabian Alps, head coach Kasper Hjulmand spoke about the importance of the fixture and the chances of qualifying for the Champions League next term.
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A quick look at the table shows the situation at FC Heidenheim is serious. The Bundesliga bottom club are already ten points behind the play-off spot with their backs to the wall in sporting terms. With eight games left to play, avoiding relegation appears to be a mission impossible. Nevertheless, they are far from flying the white flag at the Schlossberg ahead of the clash with the Werkself this Saturday, 21 March (kick-off: 15:30 CET). The lowdown on our next opponents.
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Bayer 04 Leverkusen will have to manage without the two strikers in the immediate future. Caroline Kehrer suffered a torn ligament in her right knee and Amy Wrigge tore her cruciate ligament.
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