The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

The Werkself conceded a goal at home for the first time since the beginning of January 67 minutes into the game against FSV Mainz 05 on Saturday. Jarell Quansah levelled late on for the final score of 1-1 to secure a point and avoid a first home defeat in six games. Bayer 04 were very critical of their performance after the game. The Werkself review.
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Rüdiger Vollborn has been at the club for 40 years, he holds the record number of Bundesliga appearances for the club (401) and is the only Bayer 04 player to have won both the UEFA Cup (1988) and the DFB Pokal (1993). And the Berliner stayed with the Werkself after ending his impressive playing career as he worked as a goalkeeping coach for the following nine years. Vollborn now works under the Bayer Cross as a fan liaison officer and club archivist. Since February 2021, the personalised Black and Red lexicon takes Werkself fans under the heading of 'Rudi recounts...' on a brief trip through the history of Bayer 04 every month…
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From special edition jerseys to fan banners, the home game against Mainz 05 was all about the many Bayer 04 fan clubs. Accordingly, a fitting tribute to the long-standing Werkself supporters was not to be missed during half-time in the Bundesliga match. Fernando Carro, CEO, honoured the up to 50-year anniversaries of six fan clubs in front of the coaches' benches at the BayArena.
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Werkself TV shows the highlights of Bayer 04's 1-1 draw against Mainz 05 on Matchday 24 of the 2025/26 Bundesliga season...

A late goal secured a point for Bayer 04 at home to FSV Mainz 05 in a match that saw the Black and Reds dominant in the second half. Despite lots of possession, the Werkself initially found few gaps and fell behind after 67 minutes when Sheraldo Becker scored in a Mainz counter-attack. In the closing stages, Leverkusen threw everything forward once again and equalised through Jarell Quansah (88').
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