The Black and Reds won the last two encounters: In October 1995, there was also a Round of 16 tie that ended in a 4-1 win on penalties after a 4-4 draw after extra time: Bayer 04 secured a 1-0 win in the first round in September 2002. The only time RW Essen came out on top was a 4-1 win in round three in the first DFB Cup meeting in 1981/82.
The Werkself go into Tuesday night's game as the clear favourites – Bayer 04 are in the Round of 16 for the seventh time in the last eight years and have always progressed in the cup against teams from the fourth tier or below – but Essen have already caused cup upsets against two teams this season. "In Bielefeld and Düsseldorf, they have knocked two good opponents out of the competition. RWE are a good team and we have prepared accordingly. At the end of the day, we don't want to be on the end of the next upset so we’ll have to produce a good performance tomorrow," said Peter Bosz at the pre-match press conference.
It could well be match of the season for Essen but "it's also an important game for us," Bosz made clear and he is expecting a defensive opponent. "I think we'll push them back. Essen will be compact in defence and hope to provide a threat in counter-attacks. Therefore, we have to be well organised defensively across the pitch. And, of course, score goals."
Although the results in the league have recently been below par, "we don't need to panic. We analyse what we've done wrong and then work on our game in training," assured the head coach. "Tomorrow we’ll have to take our first chance if possible and then create further goalscoring opportunities and that's how we’ll start."
There will be a late decision on who will be going in search of goals for the Werkself. A number of players suffered knocks in the Bundesliga away game at RB Leipzig. Moussa Diaby, who went off on 59 minutes after a kick on the knee, did not train on Sunday, just like Leon Bailey, who is ruled out due to illness. Only if they can complete the final pre-match training session will they be an option for the squad on Tuesday night. The final session will also be crucial for Sven Bender as well as new signing Jeremie Frimpong who was on the training ground for the first time with the team on Sunday.
In principle, Bosz is open to changes to his team but did emphasise: "We want to win. Therefore, I'll use players who I think can help us most."

Bayer 04 Leverkusen have loaned U19 midfielder Jeremiah Mensah to Dutch second-tier side Roda JC Kerkrade for one year. The 18-year-old Germany youth international has a long-term contract at the club to 2031.
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Bayer 04 kick off the final phase of their 2026/27 pre-season preparations with a friendly against Premier League club Nottingham Forest. Head coach Carles Martínez’s team will take to the pitch at the City Ground today, Wednesday 12 August (kick-off: 8.45 pm/7.45 pm local time). Werkself-TV will broadcast the match live and in full exclusively for Bayer 04 members via livestream from 8.35 pm...

Bayer 04 Leverkusen have signed Argentina international Facundo Medina. The defender, who can play both at left-back and in a more central position in the back line, has signed a contract with Bayer 04 to 30 June 2031. The 1.84-metre-tall World Cup runner-up, who will wear the number 2 shirt, joins the club from French top-flight side Olympique de Marseille.
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Villa Fiorito, River Plate, Ligue 1, the World Cup final and now Bayer 04: Facundo Medina’s life story so far has been shaped by special places, clubs, matches and names. One of them is Diego Maradona, who, like Medina, hailed from the south of Buenos Aires. Another is Exequiel Palacios, his former team-mate at River Plate, who was raving about Bayer 04 to him as recently as the World Cup in North America. Medina has now taken the plunge into the Bundesliga and, as an Argentine World Cup runner-up, has joined Bayer 04 from Olympique de Marseille this week. It is set to be the next successful chapter in his career. Leverkusen’s new number 2 brings with him a South American mentality and passion, a wealth of experience from many years in Ligue 1, and a fascinating story to the Rhineland – and to a club where the 1.84-metre-tall left-footed player will be reunited with Palacios and several other familiar faces.
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Shortly after signing his contract with Bayer 04, new signing Facundo Medina spoke to Werkself.tv about his first impressions of the club, his expectations and his conversations with his Argentine compatriot Exequiel Palacios. The defender also reveals what the fans can look forward to. Welcome to Leverkusen, Facu!
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