
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Werkself-TV shows the highlights of Bayer 04 Women's 2-1 win at SC Freiburg on Matchday 5 of the 2026/27 Google Pixel Women's Bundesliga.
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Calling Bayer 04 families – this matchday is all yours! As part of the Family Matchday on Sunday 20 September, not only will the Werkself take on RB Leipzig at 15:30 CEST but there will also be a variety of activity zones for young and old alike be set up around the BayArena. What’s more, genuine Bayer 04 rarities await Black and Red fans at the Fantrödel flea market. By taking part in the fan travel survey, Leverkusen supporters can help the club gather important information and even win a jersey before the Werkself hit the ground running against Leipzig on the pitch. The matchday news for RB Leipzig game.
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It has been a mixed start to the season for RB Leipzig. The team from Saxony have a flawless record at home but are less successful on the road to date. RBL are looking to change that in their away fixture at the BayArena on Sunday, 20 September (kick-off: 15:30 CEST). However, head coach Martin Demichelis will have to manage without a number of key players. The lowdown on our next opponents.
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With a flawless away record under their belts, the Bayer 04 women’s team travel to SC Freiburg. On Sunday 20 September (16:00 CEST), coach Roberto Pätzold’s side will be aiming for three points again, six days after their narrow defeat to Bayern Munich. The Werkself have emerged victorious from both of their away fixtures so far this season.
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