The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Ahead of Bayer 04's Europa League match away to OFI Crete in Greece, defender Jarell Quansah spoke to Werkself-TV...
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He's one of the leading figures of Leverkusen and the German economy: Werner Wenning rose from an apprentice at Bayer 04 to CEO of the global company. A childhood Werkself fan, he has held a position of responsibility at the club for many years as chairman of the shareholder committee of Bayer 04 Leverkusen Fußball GmbH. Today the Leverkusen native celebrates his 80th birthday. The entire Bayer 04 family offers its warmest wishes!
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OFI Crete have begun the UEFA Europa League league phase with one win and one defeat. The Greek Cup winners are still unbeaten at home this season, so a tricky assignment awaits the Werkself at the Pankritio on Thursday 22 October (kick-off 18:45 CEST). The lowdown on our next opponents.
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Bayer 04 Leverkusen have drafted in Jonas Hofmann to their UEFA Europa League squad. The 34-year-old attacking midfielder will travel with the Werkself to Greece tomorrow, Wednesday 21 October, ahead of the match at OFI Crete the following day. Hofmann replaces injured teammate Martin Terrier in the squad.
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