
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The Bayer 04 Women clcoked up a 3-2 win in a friendly against Twente Enschede on Thursday afternoon in the last international break of 2025. In drizzle, Lilla Turanyi (16’), Kristin Kögel (65’) and Paulina Bartz (69’) scored the goals for the Werkself against the Dutch Eredivisie Vrouwen leaders, who are still unbeaten in the league.
Show more
Brazilian legends, media and representatives of Bayer 04 Leverkusen and Bayer AG gathered at the Clube de Bayer in the south of São Paulo on Tuesday to take part in a panel discussing the club’s presence in Brazil and to watch the team’s 2–0 win over Manchester City in the Champions League. More than 50 participants from various Brazilian media were on hand. The event also included a light-hearted friendly media game prior to the match against the team of coaching legend Pep Guardiola.
Show more
The annual Black and Red Week is up and running. Day three, Thursday 27 November, includes non-kit supplier merchandise...
Show more
Werkself TV shows highlights of the 2-0 win for Bayer 04 at Manchester City on matchday 5 in the UEFA Champions League 2025/26 league phase...
Show more