
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The international break produced a full range of emotions for Bayer 04’s women. While four Leverkusen players were in play-off action to try and reach the World Cup, including two important goals, there were others in friendly action. Here’s a round-up of all the results…
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The NB Vintage Collection is here and available now! Members enjoy an exclusive priority purchase period (online shop only). Non-members will then be able to purchase items from Saturday 17 October (10:00 CEST). Sales will also begin at the same time at the Bayer 04 Fanwelt.
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Intercultural exchange: a youth team from Ouagadougou, the capital city of Burkina Faso, visited Leverkusen in the last few days. The players and staff from AD DUHA FC enjoyed a varied programme including training, a friendly - and a very special experience on Saturday afternoon.
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There will be a change at the top of the Bayer 04 Leverkusen Fußball GmbH shareholder committee at the end of the year, with Werner Wenning stepping down from the Bundesliga club's control committee on 31 December 2026. Wolfgang Nickl, who has been part of the committee since March of this year, will take over the chairmanship on 1 January 2027.
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