The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
Centre-back Melissa Friedrich is set to remain at Bayer 04 for another year. The longest-serving player in the squad, who joined the club in 2016, has extended her contract to 2027.
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Bayer 04 Leverkusen have signed Portugal U21 international Afonso Moreira. The 21-year-old winger joins the club from French top-flight side Olympique Lyon on a contract to 30 June 2031. In France last year, the left-winger made 37 appearances in Ligue 1, the Coupe de France and the UEFA Europa League, scoring a total of eight goals and providing eleven assists.
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A warm welcome to Leverkusen, Afonso Moreira! Bayer 04 have signed the 21-year-old Portuguese player from the top-flight French club Lyon. The left-winger has signed a contract at Leverkusen to 30 June 2031. Bayer04.de takes a closer look at the new signing.
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A new signing for the U19s: Bayer 04 have signed winger Clinton Wilson from Schalke 04. The 18-year-old previously played for Leverkusen youth teams from January to June 2024.
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