
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Tickets are on sale for the last two Bayer 04 Women's team home games in 2025. Fans can now purchase tickets for the matches at the Ulrich Haberland Stadium against RB Leipzig and the final fixture of the year in the Rückrunde opener against German champions Bayern Munich. The latest information at a glance.
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Eliminated ahead of the offline round: On Tuesday, 18 November, the Leverkusen console pros played the two remaining matches in the online preliminary round of showdown two. After picking up six points from the first four games last week, the #B04eSports team bagged another three in the two final duels - but it wasn't enough. The Leverkusen team missed out on a place in the offline knockout round, which will take place in this second showdown on 23 November in Frankfurt am Main.
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The VBL Club Championship by WOW 2025/26 continues today, Tuesday 18 November, with the last two of the six online preliminary round matches in the second showdown. Starting at 18:00 CET, Bayer 04 face Karlsruher SC, followed by Borussia Mönchengladbach at 19:00 CET. The games will be streamed live on the Bayer 04 app and on the club Twitch channel. The lowdown on our next opponents.
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A disappointing Sunday afternoon in the Hanseatic city: The Bayer 04 Women missed out on a place in the DFB Pokal quarter-finals after a penalty shoot-out at Hamburger SV. After more than 120 minutes of play, coach Roberto Pätzold's team lost 4-2 on penalties to the Bundesliga newcomers in front of 3,993 spectators at the Volksparkstadion. Julia Mickenhagen's brilliant strike to level at 1-1 on 73 minutes was not enough for the Werkself in this tie. The Bayer Leverkusen Women’s team reached quarter-finals in both of the previous two seasons.
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Just 11 days after their last encounter in the Bundesliga, Bayer 04 Women meet Hamburger SV again. On Sunday (15:00 CET), the two teams will be battling it out at the Volksparkstadion for a place in the DFB Cup quarter-finals. Coach Roberto Pätzold is aware of his team's status as favourites against the promoted outfit - and knows what it will come down to against the awkward opponents.
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