
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Former Bundesliga and Germany keeper Manfred Manglitz, who was promoted to the Oberliga West with Bayer 04 in 1962, passed away on Monday at the age of 86.
Show more
The FIFA World Cup 2026 in the USA, Canada and Mexico is underway. A total of eight Leverkusen players are taking part in the 23rd World Cup, with 48 teams in the tournament for the first time. Bayer04.de brings you all the latest from Werkself players at the World Cup.
Show more
Following the summer break of around two months, the Bayer 04 first team squad took to the training pitches at the BayArena for the first time on Tuesday – and the players were in high spirits. Alongside the newly formed coaching team led by head coach Carles Martínez, new signing Afonso Moreira also completed his first session with the squad. In front of several hundred Bayer 04 fans at the open session, numerous Werkself players worked up a good sweat. The Leverkusen players who took part in the World Cup will join pre-season training at a later date.
Show more
In mid-August, the Werkself will set off on a four-day trip to England to play their final two friendly matches of the 2026/27 pre-season against Premier League clubs Nottingham Forest and Newcastle United. The match in Nottingham against the Tricky Trees is on Wednesday 12 August at 20:45 CEST (19:45 BST) at the City Ground. The game against the Magpies in Newcastle is on Saturday 15 August at 16:00 CEST (15:00 BST) at the atmospheric St James’ Park. Details on ticket sales for both matches.
Show more