The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin
As with the other youth teams (U16 to U19), Bayer 04 are also relying on familiar faces—some in new roles—and fresh impetus from the coaching staff for the 2026/27 season in the younger age groups. An overview of the U11 to U15 teams.
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After eight years in the youth set-up at Bayer 04 Leverkusen, Benjamin Adam is leaving the club. The 35-year-old, who most recently coached the Leverkusen U17s, will take charge of the Hansa Rostock U19 team next season.
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As well as internal changes and familiar faces, Bayer 04 are also looking to bring fresh impetus to the coaching staff of the senior youth squads for the 2026/27 campaign. Here is an overview of the U19, U17 and U16 teams.
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Bayer 04 have signed 16-year-old defensive midfielder Kennet Eichhorn from Hertha Berlin. The Germany U17 international is joining the Werkself from the Berlin Bundesliga 2 club on a long-term contract. Eichhorn made 19 appearances for the Hertha Berlin first team last season, scoring two goals.
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