
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

In Germany, the temperatures are currently around zero, leaving even professional footballers freezing - but not the Bayer 04 Women. Roberto Pätzold's team have fled the cold to the south and are preparing for the second half of the season at a training camp in the Algarve, almost 2,000 kilometres away from home as the crow flies. The Leverkusen squad landed in Faro on Saturday morning and have already completed the first three training sessions over the weekend.
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It was a disappointing Saturday night. The Werkself lost 4-1 to VfB Stuttgart to start the new year on Bundesliga matchday 16 in 2025/26, a result that left both players and fans disappointed. "We played without any passion," said Alejandro Grimaldo honestly afterwards. Teammate Jarell Quansah was even more self-critical, emphasising: "We were miles off it in the first half. You can't put in a performance like that, especially in front of our own fans and I can only apologise to them, to be honest." Read on for the reaction, facts and stats from the clash with VfB Stuttgart in the Werkself review.
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Women’s team forward Paulina Bartz is leaving Bayer 04 Leverkusen to play for Hamburg SV until the end of the season. The 20-year-old, whose contract runs to 2027, joins the Bundesliga newcomers on loan until the summer.
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Jarell Quansah and Alejandro Grimaldo speak to Werkself-TV following Bayer 04's 4-1 defeat to VfB Stuttgart on Bundesliga Matchday 16...
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