
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

The Werkself face Manchester City for the very first time on Tuesday for Matchday 5 of the league phase in the 2025/26 UEFA Champions League (kick-off: 21:00 CET). The hosts sit fourth in the standings and boast huge quality in attack, while Leverkusen are looking to improve their meagre record of just one win from the last 10 games away at English clubs. A key player in that regard could be Aleix Garcia, the former City midfielder who ranks highly in several passing metrics in the Champions League this season. Here’s all you need to know ahead of the game in our matchday news.
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The Werkself's next European trip takes them to the north-west of England as Kasper Hjulmand's side take on Manchester City on Tuesday, 25 November (kick-off: 21:00 CET) on Matchday 5 in the league phase of the 2025/26 UEFA Champions League campaign. As usual, we'll take you along on the #aCROSSeurope journey and report from Manchester. All times listed are in CET.
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The dress rehearsal in the Premier League for the match against the Werkself did not go well at the weekend. However, Manchester City are still unbeaten in the UEFA Champions League, the competition they won in 2023. In the first encounter with Bayer 04 this Tuesday, 25 November (kick-off: 21:00 CET), coach Pep Guardiola will be able to field just about his best line-up. The lowdown on our next opponents.
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Will the Bayer 04 U19s take the next step towards their first appearance in the knockout stage of the UEFA Youth League in the away game at Manchester City? Coach Kevin Brok is well aware of this historic opportunity, but he's not about to start worrying about the maths: "We're not concerned with the question of what might be good enough. We invest everything we can and always aim for the maximum. That's our way." The game on this penultimate Matchday 5 of the league phase takes place on Tuesday, 25 November (kick-off: 16:00 CET) at the Manchester City Academy Stadium. Werkself TV will be broadcasting the whole match exclusively for Bayer 04 club members live from 15:50 CET....
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Charitable commitment under the cross: Bayer 04's U19s have donated the contents of their team kitty from the 2024/25 season to the charitable project ‘Wishes come true’. Defender Ferdinand Pohl, on behalf of the entire team, handed over a whopping €1,150 in the form of a symbolic cheque at the BayArena this week.
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