
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Ken Izekor is leaving Bayer 04 Leverkusen to join third-tier side Alemannia Aachen with immediate effect. The 19-year-old centre-forward joined the club from Alemannia in 2018, and Izekor is now returning to his hometown.
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The Golden Boy Top 100 traditionally lists Europe’s most promising young players. In the latest update, published to mark the start of the new season, four current Werkself players – alongside loanee Francis Onyeka – feature on the list. This means Bayer 04 have the most players in contention of any Bundesliga club.
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Bayer 04 have named Jorginho, a 1994 World Cup winner with Brazil, an official club legend. He is the second former Werkself player, after Paulo Sergio, to be accorded this special honour. For many years, the former Leverkusen defender has been deeply committed to helping people in need in his home city of Rio de Janeiro. More than 25 years ago, Jorginho launched the Bola pra Frente project, through which he uses the money he earned as a player – including during his time at Bayer 04 – to support children and young people in the favelas in particular. During a trip to Brazil lasting several days, Fernando Carro, CEO at Bayer 04, assured Jorginho of the club’s support for Bola pra Frente for at least another five years.
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Goalkeeper Rafaela Borggräfe will continue to play for Bayer 04 Leverkusen next season. The loan of the Germany U23 international, who joined from Liverpool in the winter, has been extended by a further year.
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The Bayer 04 delegation, led by Fernando Carro, CEO, concluded their multi-day trip to Brazil with a visit to the community-based organisation Bola Pra Frente in Rio de Janeiro – founded by former Werkself player Jorginho. During the visit, Bayer 04 committed to extending support for the Bola Pra Frente project for a further five years. In addition, Jorginho, a member of the Brazil 1994 World Cup-winning squad, was named Bayer 04’s second official club legend. With the visit to São Paulo and Rio de Janeiro, the club has strengthened the relationships built up over the years in one of Bayer 04’s most important international markets.
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