
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Tickets for the first two Bayer 04 women’s team home games are now on general sale. A week after their league opener away at RB Leipzig, Roberto Pätzold’s side will face last season’s runners-up, VfL Wolfsburg, in the first home fixture on Sunday 30 August (kick-off: 16:00 CEST). Fifteen days later, on Monday night, 14 September (kick-off: 18:00 CEST), the Leverkusen Women host German champions Bayern Munich at the Ulrich Haberland Stadium for a top-of-the-table league clash. You can now also select specific seats via the online shop. The latest information on match ticket sales.
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Bayer 04 Leverkusen have extended midfielder Noah Mbamba’s contract by twelve months and sent the Belgian U21 international on loan to France. At FC Lorient, the 21-year-old – whose contract at Leverkusen now runs to 30 June 2029 – is set to gain playing time in Ligue 1 and, through strong performances and further development, put himself in the running for a future place in the Werkself squad.
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Werkself TV shows the highlights of the 2-1 victory in the friendly match against FC Sevilla...
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Back at the BayArena at last! For the first time since the summer break, the Werkself played at their home ground in the 2026 season launch – and went on to beat Sevilla in the fifth preseason friendly. Patrik Schick turned the game around after Miguel Sierra put the visitors ahead (16’), scoring twice in the second half (66’, 79’) to the delight of the Bayer 04 fans in the new seats at the BayArena. New signing Miguel Gutiérrez was delighted to provide the assist for the equaliser on his debut under the Bayer Cross.
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