
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

After eight years in the youth set-up at Bayer 04 Leverkusen, Benjamin Adam is leaving the club. The 35-year-old, who most recently coached the Leverkusen U17s, will take charge of the Hansa Rostock U19 team next season.
Show more
There was a successful end to the women's internationals with Werkself players Carlotta Wamser and Cornelia Kramer qualifying for the 2027 World Cup finals in Brazil. A third Leverkusen player is still in with a chance of joining them. The Germany U23 players also experienced success in their last two international friendlies of the season.
Show more
Traveling to North America for the World Cup this summer to see your favorite Bayer 04 players? Here’s a quick cheat sheet with thumbnail portraits and insider tips for each city from a local expert, so you can make the most of your visit and activities beyond the game!
Show more
A fresh look for the BayArena: The Bayer 04 stadium will have new seating in the form of folding seats for the 2026/27 campaign that will ensure significantly improved seating comfort and simplified movement within the rows of seats. As part of routine replacement after 17 years, fans of the Werkself were able to purchase the existing seats, used to witness the first German league title in the club's history. In addition, a large proportion of the seats will be donated to charitable projects, primarily in the local region. Bayer 04 fans can look forward to new, functional folding seats for the season opener at the beginning of August - still in the club colours of black and red, of course. A glimpse at the BayArena during the refurbishment.
Show more