
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Reinforcement in attack: Bayer 04 Leverkusen have secured the transfer of striker Maja Sternad from Bundesliga rivals SV Werder Bremen. The 22-year-old has signed a contract until 30 June 2028.
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It's a thrilling situation: as the season draws to a close, Stuttgart and Bayer 04 are heading into the home stretch almost neck and neck. After 32 games, with 17 wins, seven draws and eight defeats each, both teams are on 58 points. Even in terms of goals scored, VfB and the Werkself are level on 66. The Black and Reds have conceded just three fewer goals (43) than their rivals (46), which is why they sit one place behind fourth-placed Leverkusen. This Saturday, 9 May (kick-off: 15.30 CEST), the two teams go head to head at the MHP Arena in Stuttgart. The lowdown on our next opponents.
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Bayer 04 Leverkusen have extended the contract with full-back Arthur ahead of schedule. The Werkself have agreed a new deal with the Brazilian to 30 June 2031. The 23-year-old was previously under contract to the summer of 2028.
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Bayer 04 Leverkusen continue building the squad for the new season in the Google Pixel Women's Bundesliga. The 25-year-old midfielder Marlene Müller has joined the club from RB Leipzig on a contract to 30 June 2028.
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Bayer 04 are introducing changes to the ticket price structure for the 2026/27 season. In addition to adjusting the ticket prices, the ticket categories will also be reorganised. All season ticket holders have already been informed of the changes by e-mail. The most important information at a glance.
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