
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Barely two weeks since beating St. Pauli in the DFB Pokal quarter-finals, Bayer 04 again welcome the Hamburg club to the BayArena for Matchday 22 in the Bundesliga this Saturday (kick-off: 15:30 CET). The visitors received a welcome confidence boost last weekend with a win over VfB Stuttgart, but the head-to-head record is still very much in Leverkusen’s favour, which Kasper Hjulmand’s team will look to maintain. Here’s all you need to know ahead of the game in our matchday news.
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Werkself-TV shows the highlights of the Bayer 04 women's 2-1 win against FC Köln on the 18th matchday of the Google Pixel Frauen-Bundesliga 2025/26.
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In preparation for the Bundesliga home match against FC St. Pauli on Saturday, 14 February (kick-off: 15:30 CET), the Werkself had a full week of training for the first time since the first match in 2026. At the press conference ahead of the clash against the relegation-threatened Kiezkicker, coach Kasper Hjulmand spoke about the intensive work during the week and the lessons learnt. The Dane also announced the good news that Ibrahim Maza is available again.
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Bayer 04 Leverkusen are strengthening the squad for next season with the addition of Serbia U19 international Aleksa Damjanovic. The 17-year-old centre-forward is set to join the Bundesliga club in the summer from Serbian champions Red Star Belgrade. Damjanovic, who also has Austrian citizenship, has signed a long-term contract.
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