
The second round will be played on Tuesday 26 October and Wednesday 27 October. Exact fixture details will be announced in due course. Then the start of ticket sales will be released.
Sporting director Simon Rolfes: "KSC are an interesting opponent, a team with ambition in the second division. We are at home and we want to live up to our role as favourites."
Head coach Gerardo Seoane: "I'm looking forward to this game as the cup competition is something special. Of course, we face certain expectations as the higher placed club. But we also have them ourselves. The next round is the clear target and that's how we want to approach the game against Karlsruhe from the start."
While the Werkself and KSC have played each other 34 times in the Bundesliga the two sides have only meant once before in the DFB Cup. That was a first-round tie at the Wildpakstadion on 11 August 2017. KSC had just been relegated from the second division but performed well and took the game to extra time with a certain amount of luck. Bayer 04 were then able to turn their visual superiority into goals on the scoreboard. Dominik Kohr, Joel Pohjanpalo and Leon Bailey netted the goals in a 3-0 win. The Werkself went through to the second round and only went out of the cup competition at the semi-final stage against Bayern Munich.
Preußen Münster vs Hertha BSC
Waldhof Mannheim vs Union Berlin
VfL Osnabrück vs SC Freiburg
SV Babelsberg vs RB Leipzig
1860 München vs Schalke 04
Hannover 96 vs Fortuna Düsseldorf
VfL Bochum vs FC Augsburg
Borussia Mönchengladbach vs Bayern Munich
Dynamo Dresden vs FC St. Pauli
TSG Hoffenheim vs Holstein Kiel
Jahn Regensburg vs Hansa Rostock
FC Nürnberg vs Hamburg SV
FSV Mainz 05 vs Arminia Bielefeld
VfB Stuttgart vs FC Köln
Borussia Dortmund vs FC Ingolstadt
Round of 16: 18 and 19 January 2022
Quarter-finals: 1 and 2 March
Semi-finals: 19 and 20 April
Final: 21 May in Berlin

Job done: the Bayer 04 eSports team defeated SV Darmstadt 98 in the play-offs to secure their consecutive participation in the VBL Club Championship final. The journey continues now for Leverkusen on Saturday 7 March (from 17:00 CET) with a last-16 encounter at Hamburger SV.
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Werkself TV shows highlights of the 0-0 draw against Olympiacos in the second leg of the play-offs of the UEFA Champions League 2025/26 league...
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A disciplined defensive performance in the second leg saw Bayer 04 prevail against Olympiacos in the play-offs of the UEFA Champions League 2025/26. Thanks to the 2-0 away win in the first leg, the goalless draw at home at the BayArena was enough to ensure progress to the next round. The Black and Reds kept their opponents away from their goal for the best part of 90 minutes.
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Bayer 04 can go through to the Round of 16 of the UEFA Champions League for the ninth time tonight, 24 February (kick-off: 21:00 CET) and be in the top 16 clubs in Europe. A good omen: Leverkusen have progressed to the next round after winning the first leg in 20 of their 22 knockout rounds in European competitions to date. For their part, Greek record champions Olympiacos rested several players for last weekend’s league fixture ahead of the play-off second leg at the BayArena and will now do everything in their power to turn the tide with their usual aggressive and high pressing. The discussions on Werkself radio are likely to be just as intense as the battle on the pitch, with commentator Florian Bechholz welcoming honorary captain Stefan Kießling and goalkeeper Mark Flekken. Today’s matchday news.
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Bayer 04 Leverkusen will play Offenbacher Kickers: As part of the 125th anniversary celebrations of the regional football league club, the Werkself will play a friendly at the Hessen club in the summer. On Saturday, 25 July 2026 (kick-off: 15:00 CEST.), coach Kasper Hjulmand's team will face OFC at Offenbach's Bieberer Berg stadium. The supporters of both clubs have maintained a close fan friendship for many years. This makes the match in preparation for the 2026/27 season a very special one, and not just for Offenbach fans.
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