The former goalkeeper Andrés Palop, in the Werkself squad in 2013/14, helped draw out the clubs. The first leg will be played on 10 March and the return match is a week later on 17 March. Bayer 04 are away first.
Fernando Carro, Bayer 04 CEO, commented on the draw: "Atalanta are a good opponent, it's always difficult to play against Italian teams." However, the 57-year-old is confident. Carro continued: "I'm optimistic we will successfully master this hurdle and put ourselves in a good position in the first leg away from home."
Sporting director Simon Rolfes added: "Atalanta are one of the best teams in Italy and have developed really well in recent years. They like to get forward and they score lots of goals. For me, this tie is one of the top matches in this round." The future Leverkusen sporting managing director set out the target: "Our aim is to go through. We are at home in the second leg and I'm hoping we can fill the stadium by that time."
Away tickets for the first leg of the Round of 16 in Bergamo (10 March) go on sale on Monday 7 March. Tickets for the second leg at the BayArena (17 March) are available from Tuesday 8 March.
Round of 16:
Rangers vs Red Star Belgrade
Sporting Braga vs AS Monaco
FC Porto vs Lyon
Atalanta vs Bayer 04 Leverkusen
FC Sevilla vs West Ham United
FC Barcelona vs Galatasaray
RB Leipzig vs Spartak Moscow
Real Betis vs Eintracht Frankfurt
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