This will be the fourth DFB Cup tie between the two Bundesliga rivals. The previous meeting was in the quarter-finals of the 2019/20 season with the Werkself Women winning 3-2 after extra time.
Bayer 04 beat second division RB Leipzig 3-1 in the second round to qualify for the Round of 16; TSG went through to the next round with a 5-0 win at Regional League FC Würzburger Kickers.
The Round of 16 ties will be played on 30 and 31 October. Sky will broadcast a top game in each round.
Turbine Potsdam vs FC Köln
SC Freiburg vs VfL Wolfsburg
Bayer 04 vs TSG Hoffenheim
Bayern Munich vs Eintracht Frankfurt
Werder Bremen vs SC Sand
Karlsruher SC vs FC Carl Zeiss Jena
Sportfreunde Siegen vs SV Henstedt-Ulzburg
Hamburg SV vs SGS Essen
Edmond Tapsoba has signed an early extension to his contract with Bayer 04 Leverkusen. With two years left on his current deal, the 27-year-old Burkina Faso international has extended his contract until 30 June 2031. The centre-back joined as a young talent from Portuguese top-flight club Vitoria Guimaraes at the start of 2020.
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A special surprise: during the preview for the 'Fierté Burkinabè' documentary about Edmond Tapsoba, Bayer 04 directors Fernando Carro and Simon Rolfes announced Tapsoba's contract extension until 2031 together with the centre-back. He then spoke to Werkself-TV about his time in Leverkusen so far and future ambitions...
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This evening was deeply moving: At a really special setting, Bayer 04 exclusively presented the specially produced documentary ‘Fierté Burkinabè’ ("Burkinabe Pride") about Edmond Tapsoba on Tuesday. For the preview at the BayArena, the parents of the Werkself player and other close companions travelled all the way from his African homeland Burkina Faso. The 45-minute film shows Tapsoba's extraordinary career from his beginnings in Ouagadougou to Leverkusen as well as the work of his foundation "Fondation Edmond Tapsoba", with representatives from Burkina Faso also present. Fans can watch the documentary free of charge on Werkself TV and YouTube from Wednesday night at 20:00 CEST.
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Bayer 04 have signed left-back Carolin Simon from champions Bayern Munich for the coming season. The 33-year-old former Germany international, who played for Leverkusen from 2013 to 2016, has signed a contract to 30 June 2028.
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Bayer 04 Women have strengthened for the coming season with the signing of Lobke Loone. The 23-year-old Dutch striker joins from Utrecht on a contract until 30 June 2028.
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